Endocrine Abstracts

All forms of severe lipodystrophy are associated with features of the metabolic syndrome including insulin resistance, T2DM, NAFLD, dyslipidaemia and cardiovascular disease. The question I will address is if this means that what happens in patients with monogenic forms of lipodystrophy is at all relevant to common forms of insulin resistance and the metabolic syndrome....

Acquired lipodystrophies (AL) are syndromes characterized by an irreversible loss of subcutaneous adipose tissue and are conventionally distinct in partial (Barraquer-Simons) or generalized forms (Lawrence Syndrome) based on the pattern of adipose tissue disappearance. Alike to congenital forms, AL exhibit metabolic abnormalities that include insulin resistance, diabetes mellitus, hypertliglycerdidemia, reduced leptin levels, hepatomegaly and steatosis. While in most cases of ...

Lipodystrophy syndromes are rare heterogeneous disorders characterized by deficiency of adipose tissue, and, frequently associated, but not always, to severe metabolic abnormalities including diabetes mellitus and dyslipidemia. With the exception of HIV-associated lipodystrophy, the other distinct subtypes of lipodystrophy are very infrequent, so they are considered rare diseases. Lipodystrophy is classified as genetic or acquired and by the distribution of fat loss, which can...