ECE2018 Poster Presentations: Thyroid Thyroid (non-cancer) (105 abstracts)
Changes of visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroidism
Nadia Sawicka-Gutaj 1 , Ariadna Zybek-Kocik 2 , Michal Kloska 3 , Agata Czarnywojtek 1, , Jerzy Sowinski 1 , Bartlomiej Budny 1 , Kosma Wolinski 1 , Katarzyna Ziemnicka 1 , Dorota Mankowska-Wierzbicka 5 & Marek Ruchala 1
1Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland; 2Department of Endocrinology, Metabolism and Internal Medicine, Poznan Univeristy of Medical Sciences, Poznan, Poland; 3Department of Gastroenterology, Internal Medicine, Metabolic Diseases and Dietetics, Poznan University of Medical Sciences, Poznan, Poland; 4Department of Pharmacy, Poznan Univeristy of Medical Sciences, Poznan, Poland; 5Department of Gastroenterology, Internal Medicine, Metabolic Diseases and Dietetics, Poznan Univeristy of Medical Sciences, Poznan, Poland.
Purpose: The aim of the study was to investigate changes of visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients.
Material and methods: The study was designed as a single-center, cross-sectional with consecutive enrollment. We included all patients with newly diagnosed overt hyperthyroidism (Graves’ disease or toxic nodular goiter). Each subject underwent physical examination, laboratory investigation, body composition analysis, and thyroid ultrasound. NAMPT mRNA leukocyte expressions were measured using RT-qPCR.
Results: Initially, 173 patients were eligible for the study, and due to exclusion criteria 95 were enrolled in further analysis (67 patients with Graves’ disease (GD) and 28 with toxic nodular goiter (TNG)). Forty three healthy volunteers adjusted for age, sex and BMI served as a control group. We found higher NAMPT/visfatin serum concentration in patients with GD than in patients with TNG (P=0.03855). NAMPT leukocyte expression was significantly higher in GD patients (n=32) as compared to TNG patients (n=18) and euthyroid controls (n=24)(P=0.005965). Simple linear regression analysis revealed that NAMPT/visfatin serum concentration was significantly associated with NAMPT leukocyte expression, thyroid autoimmunity, age, HOMA-IR, and fat mass percentage (FM%). NAMPT leukocyte expression was associated with thyroid autoimmunity, age, and TRAb levels. The stepwise multiple regression analysis confirmed FM%, HOMA-IR as independent predictors of visfatin/NAMPT serum levels. In a separate stepwise e multiple regression analysis, we confirmed the association between NAMPT leukocyte expression and TRAb levels.
Conclusions: We found that visfatin/NAMPT serum elevation in hyperthyroid patients is related to fat mass percentage together with HOMA-IR. Observed NAMPT leukocyte overexpression in GD patients and its association with TRAb levels suggest potential involvement of visfatin/NAMPT in pathogenesis of thyroid autoimmunity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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