ECE2018 Poster Presentations: Thyroid Thyroid (non-cancer) (105 abstracts)
Effectiveness of radioiodine treatment for toxic adenoma
Ana Sofia Osório 1 , Ana Filipa Martins 1 , Raquel Vaz de Castro 1 , Vânia Gomes 1 , Carolina Faria 1 , Ema Nobre 1 , Mickael Antoine Ferreira 2 , Guilhermina Cantinho 3 & Maria João Bugalho 1
1Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte EPE, Lisbon, Portugal; 2Statistical Independent, Lisbon, Portugal; 3Instituto de Medicina Nuclear da Faculdade de Medicina de Lisboa, Lisbon, Portugal.
Objective: The purpose of this study was to assess clinical outcomes of patients with toxic adenoma (TA) treated with Radioactive Iodine (RAIT) in a tertiary hospital over a period of 8 years. We also analysed the influence of age, gender, TSH at diagnosis and anti-thyroid drugs (ATD) previous to RAIT on the cure rate.
Methods: Retrospective analysis of clinical records of all patients with TA submitted to RAIT between 2008 and 2015. The influence of demographic variables (age and gender) as well as clinical ones (TSH at diagnosis, iodine activity administered and previous ATD) on effectiveness of RAIT, 1 year after last treatment, was tested. Treatment success was defined by the achievement of euthyroidism or hypothyroidism 1 year after the last RAIT administration. For statistical analysis we considered a confidence interval of 95% (sig<0.05).
Results: Over 8 years, 138 patients (female 110; male 28) mean age of 60.3±14.6 years-old with TA were submitted to radioiodine treatment. Most patients were submitted to 10 or 5 mCi (61.8%–10 mCi; 35.8%–5 mCi) in a total of 145 treatments. Thirty-nine patients were lost for follow-up (28.3%). The global cure rate was of 82.8%. Hypothyroidism was observed in 32.3%. Age, gender and TSH at diagnosis had no influence on the outcome. Previous ATD was negatively correlated with the effectiveness of the radioiodine treatment. The cure rate achieved with activities of 5 and 10 mCi was slightly different, 75.6% and 88.7% respectively, but not statistically significant.
Conclusion: One year after RAIT, the cure rate of TA patients treated with an activity of 10 mCi was of 88.7% (euthyroidism 54.7%+hypothyroidism 34.0%); with an activity of 5 mCi was of 75.6% (euthyroidism 51.2%+hypothyroidism 24.4%). It is likely that for a longer period of follow-up these results might be different. Administration of ATD before radioiodine had a negative impact in therapy effectiveness.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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