ECE2018 Poster Presentations: Thyroid Thyroid (non-cancer) (105 abstracts)
Dependency between vitamin D3 and serum titers of the thyroid autoantibodies in smoking cigarettes patients with Graves’ disease - one year follow-up - preliminary study
Maria Teresa Płazińska 1 , Agata Czarnywojtek 2, , Małgorzata Zgorzalewicz-Stachowiak 4 , Nadia Sawicka-Gutaj 2 , Barbara Czarnocka 5 , Kosma Woliński 2 , Adam Maciejewski 2 , Hanna Komarowska 2 , Maria Maria Karlińska 6 , Marek Ruchała 2 & Leszek Królicki 1
1Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland; 2Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland; 3Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland; 4Laboratory of Medical Electrodiagnostics, Department of Health Prophylaxis, University of Medical Sciences in Poznan, Poznan, Poland; 5Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland; 6Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Warsaw, Poland.
Purpose: The aim of this study was to evaluate the association between the serum vitamin D level and changes in the titers of the anti-TSH receptor (TSHR), antithyroglobulin (Tg), and antiperoxidase (TPO) autoantibodies (Abs) in smoking cigarette Graves’ disease (GD) patients, with and without the vitamin D supplementation.
Methods: The study was performed from January 2015 to December 2016. It consisted of 136 patients. The intensity of nicotinism was assessed based on the Fagerström Test for Nicotine Dependence. Serum vitamin D level and the titers of TSHR-Abs, TPO-Abs, and Tg-Abs were analyzed retrospectively. Studied parameters were analyzed at entry and 1, 6 and 12 months following baseline.
Results: The titers of TSHR-Abs were significantly higher at baseline in GD patients treated with vitamin D3 {D3(+)} than in patients not receiving vitamin D3 {D3(−)} (8.9 vs 0.7 IU/ml, P<0.001); at the remaining time points, no statistically significant differences were noted. Among the GD D3(−) patients, the titers of TSHR-Abs were statistically significantly lower at baseline (Me: 0.7 IU/ml) than for each subsequent time of point (Me: 7.8, 6.6, 6.2 IU/ml; P<0.05). In the group of GD D3(+) patients, the titers of TSHR-Abs at baseline were comparable to the level after 1 (Me: 8.9 vs 18.5 IU/ml, P=NS) and 12 months (Me: 6.1 IU/ml, P=NS) of follow-up. There was a significant difference between 1 and 6 (Me: 18.5 vs 11.8 IU/ml, P<0.001), 6 and 12 months (Me: 11.8 vs 6.1, P<0.001) of observation. The titers of TPO-Abs at baseline in the GD D3(+) patients were significantly higher than in GD D3(−) patients (290 vs 38 IU/ml, P<0.001). At all subsequent time points, we noticed no significant difference. In the GD D3(+) patients, the titers of Tg-Abs at baseline were significantly higher than in GD D3(-) patients (97 vs 24 IU/mL, P=0.002). At all subsequent time points, there were statistically significantly smaller differences after one month (243 vs 92 IU/ml, P=0.03), and after 6 (220 vs 104 IU/ml, P=0.009), and 12 months (200 vs 52 IU/ml, P=0.001) of the follow-up.
Conclusion: In almost all cases, we observed that vitamin D does not have a strong association with the titers of thyroid autantibodies. Nicotine does not allow the reduction of the titers of TSHR-Abs in GD patients supplemented with vitamin D3.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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