ECE2018 Poster Presentations: Thyroid Thyroid cancer (88 abstracts)
Chronic lymphocytic thyroiditis is associated with decreased staging of differentiated thyroid cancer
Martyna Borowczyk , Adam Janicki , Grzegorz Dworacki , Ewelina Szczepanek-Parulska , Mateusz Danieluk , Jonathan Barnett , Magdalena Antonik , Małgorzata Kałużna , Barbara Bromińska , Rafał Czepczyński , Maciej Bęczyk , Katarzyna Ziemnicka & Marek Ruchała
Poznan University of Medical Sciences, Poznan, Poland.
Introduction: Despite numerous studies, the biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.
Materials and methods: Complete medical records of 907 consecutive patients with DTC treated at a single tertiary care department of endocrinology in the years 1998–2016 were subjected for analysis. The patients were divided into two groups according to the presence (studied group) or absence (control group) of concomitant CLT. Particular parameters were evaluated and compared between the groups. The statistical differences were analysed.
Results: Out of 907 patients included in the study, 331 were diagnosed with DTC and CLT (studied group) while 576 patients with DTC but without CLT constituted a control group. There was no difference in the distribution of papillary and follicular thyroid cancer in both groups. Patients from the studied group were younger than controls at the moment of diagnosis. The prevalence of pT1 was greater than for pT2-pT4 DTC (P=0.0003; OR=1.69, range: 1.27–2.24) in the studied group compared to controls (68.3% vs 56.1% respectively). The thyroid capsule infiltration without extrathyroidal invasion was more frequent (P<0.0001) and post-thyroidectomy TgAb levels were greater (P<0.0001) but Tg levels were lower (P<0.0001) in the studied group. The presence of multifocal lesions was similar in both groups. Multivariate regression analysis confirmed that the protective factors against higher tumour staging (pT2-pT4) were female sex, papillary, unlike follicular, thyroid cancer and the co-occurrence of CLT.
Conclusions: The collected data indicate a protective role of CLT in preventing spread of the DTC. The presence of CLT might possibly limit tumour growth to primary site.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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