ECE2018 Poster Presentations: Thyroid Thyroid cancer (88 abstracts)
The role of platelet activation and inflammation in patients with differentiated thyroid cancer
Sorina Martin 1, , Oana Ion 3 , Andreea Grigore 4 , Oana Enache 2 , Anca Sirbu 1, , Carmen Barbu 1, , Cosmin Giulea 5, , Adrian Miron 5, , Florin Andrei 7 & Simona Fica 1,
1Carol Davila University of Medicine and Pharmacy, Endocrinology Department, Bucharest, Romania; 2Elias Hospital, Endocrinology Department, Bucharest, Romania; 3Fundeni Clinical Institute, Nephrology Department, Bucharest, Romania; 4Fundeni Clinical Institute, Gastroenterology Department, Bucharest, Romania; 5Elias Hospital, Surgery Department, Bucharest, Romania; 6Carol Davila University of Medicine and Pharmacy, Surgery Department, Bucharest, Romania; 7Elias Hospital, Pathology Department, Bucharest, Romania.
Background: The role of inflammation in the pathogenesis of cancer and the mechanisms through which platelets can influence the aggressive behaviour of different types of cancer have been highlighted by a few studies.
Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between 2012 and 2015. We assessed the relationship between differentiated thyroid cancer (DTC) and mean platelet volume (MPV), platelet count and serum fibrinogen level in a case-control study.
Results: The study included 86 patients with DTC (mean age 53.99±13.91 years, 83.7% females) and a control group of 66 patients with histologic benign thyroid disorders (mean age 50.14±13.05 years, 83.3% females). Patients with DTC had a higher level of serum fibrinogen compared to patients in the control group (P=0.033). We did not find any significant differences between case and control groups regarding MPV (P=0.150) or platelet count (P=0.342) levels. MPV was not significantly different between histologycal subgroups of DTC patients depending on: TNM staging (P=0.308), tumor subtype (P=0.108), vascular invasion (P=0.829), capsular invasion (P=0.357), extracapsular extension (P=0.161), local lymph nodes metastasis (P=0.362). In DTC patients, the platelet count was higher in patients with higher tumour diameters (P=0.024) and capsular invasion (P=0.044). In DTC patients platelet count was significantly lower after the surgery compared to preoperatory values (P=0.050).
Conclusions: Our data showed that, when compared to benign thyroid disorders, DTC was associated with a higher level of inflammation. In DTC patients, platelet count can be associated with aggressive tumor behaviour.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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