ECE2018 Poster Presentations: Thyroid Thyroid cancer (88 abstracts)
Thyroid ultrasonographic characteristics and Bethesda results after FNAB
Fotini Kanouta 1 , Eleni Triantafillou 1 , Georgios Papadakis 2 , Styliani Kalaitzidou 1 , Aspasia Drosou 1 , Aggeliki Sapera 1 , Dimitra Tampouratzi 1 , Michalis Kotis 1 , Taxiarchis Kyrimis 1 , Anna Drakopoulou 1 , Victoria Kaltzidou 1 , Eirini Veniou 1 , Chrysa Karavasili 1 , Styliani Plyta 3 & Athanasia Tertipi 1
1Endocrinology Department, Metaxa Anticancer Hospital, Piraeus, Greece; 2STEPS Stoffwechselzentrum, Biel/Bienne, Switzerland; 3Cytology Department, Metaxa Anticancer Hospital, Piraeus, Greece.
Objectives: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules. The Bethesda System (B) classifies thyroid cytological patterns into six categories (B1-6) according to risk for malignancy.
Methods: A total of 1113 patients (210 males/903 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.2±21.6 years±S.D. We correlated the demographic profile (age and gender) and sonographic features of these nodules with the FNAB outcome. The Bethesda system for reporting thyroid cytopathology was used.
Results: Out of total 1113 cases, 255 (22.9%) cases were diagnosed as non diagnostic (B1), 780 (70.1%) were diagnosed as benign (B2), 35 (3.1%) as B3 (atypia/follicular lesion of undetermined significance), 10 (0.9%) as B4 (follicular neoplasm or suspicious for follicular neoplasm), while 13 (1.2%) cases were categorized as B5 (suspicious for malignancy) and 20 (1.8%) as B6 (malignant). Remarkably, 11 nodules of 33 of category B5 and B6 each had a maximum diameter of less that 1 cm. When comparing benign result (B2) vs. result of category B3–6 irregular shape (6.5% in B2 vs. 15.4% in B3–6, P=0.004), ill-defined margins of the nodule (10.6% in B2 nodules vs. 20.5% in B3-6 nodules, P=0.033), the presence of calcifications (24.2% in B2 nodules vs. 65.4% in B3-6 nodules, P<0.001) and the hypoechogenity of nodule (41.9% in B2 vs. 65.4% in B3-6, P<0.001) decreased significantly the possibility for benign (B2) result, whereas features such as the size of nodule, the presence of central vascularity, the composition and the heterogeneity of parenchyma did not affect the possibility for B2 vs. B3–6 result (P>0.05). Finally, there was no association of gender and age with the Bethesda category result.
Conclusions: Our study supports that the irregular shape of a nodule, ill-defined margins, the presence of calcifications and the hypoechogenenity of a nodule decrease the possibility of a Bethesda benign result. FNAB of nodules <10 mm may reveal suspicious or positive for malignancy cytology.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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