ECE2018 Poster Presentations: Reproductive Endocrinology Female Reproduction (48 abstracts)
Association of hormonal and metabolic status with carotid intima-media thickness in women with polycystic ovary syndrome
Jelica Bjekic-Macut 1 , Ivana Bozic-Antic 2 , Snjezana Erceg 2 , Milorad Civcic 2 , Dusan Ilic 2 , Danijela Vojnovic-Milutinovic 3 , Olivera Stanojlovic 4 & Djuro Macut 2
1CHC Bezanijska Kosa, Belgrade, Serbia; 2Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Women with polycystic ovary syndrome (PCOS) have numerous risk factors that lead to higher risk for cardiovascular diseases (CVD) and stroke. Measurement of carotid intima-media thickness (CIMT) is a marker of CVD.
Methods: We analyzed 399 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 25.5±5.1 years, BMI: 24.9±6.2 kg/m2), and 82 BMI-matched healthy controls (age 29.2±5.9 years, BMI 25.3±8.6 kg/m2). In follicular phase of menstrual cycle we determined fasting serum fasting glucose (FG), insulin, lipids, CRP, testosterone, SHBG, DHEAS, 17OH-progesterone, androstenedion, estradiol, TSH, fT4, CIMT and blood pressure (BP). HOMA and FAI were calculated. Differencies between groups were age adjusted.
Results: PCOS had higher total cholesterol-TC (P=0.02), LDL-C (P=0.03), triglycerides (P=0.02), HOMA-IR (P=0.04), testosterone (P<0.001), FAI (P<0.001), DHEAS (P<0.001), androstenedione (P=0.02), 17Ohprogesterone (P=0.005), systolic and diastolic BP (P=0.004 and P=0.001, respectively), and lower HDL-C (P=0.02), SHBG(P<0.001) and estradiol (P=0.04). There were no between-group differences in CIMT, CRP, glucose, TSH, fT4. Significant correlations among PCOS were obtained for CIMT and BMI (r=0.10, P=0.04), triglycerides (r=0.11, P=0.33), estradiol (r=−0.14, P=0.013), systolic and diastolic BP (r=0.13, P=0.01 and r=0.18, P=0.001, respectively). There were no correlations between androgens and CIMT among PCOS.
Conclusions: Although women with PCOS have higher CVD risk, we did not show differences in CMIT in our PCOS women in comparison to respective BMI matched controls. Overall, there are no associations between CIMT and androgen status or insulin resistance in our examined group of PCOS women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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