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Endocrine Abstracts (2018) 56 P947 | DOI: 10.1530/endoabs.56.P947

1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.


Introduction: Hyperandrogenism (HA) is frequent but not universal characteristic in women with polycistic ovary syndrome (PCOS). According to the ESHRE/ASRM definition, hyperandrogenism criterion could be clinical (hirsutism) and/or biochemical (hiperandrogenemia). The aim of this study was to analyze metabolic and hormonal characteristics among women with PCOS with different forms of hyperandrogenism.

Methods: We analyzed 458 women with PCOS diagnosed using ESHRE/ASRM criteria and divided into three groups: 1) with clinical HA only (PCOS-CHA:N=67, age: 26.7±5.6 years, BMI: 23.6±5.2 kg/m2), 2) with biochemical HA only (PCOS-BHA:N=151, age: 25.5±5.3 years, BMI: 24.5±6.5 kg/m2), 3) with both clinical and biochemical HA (PCOS-CBHA:N=240, age: 25.0±5.2 years, BMI: 26.4±6.2 kg/m2), and 104 healthy controls (age:29.2±5.8 years, BMI: 25.4±16.8 kg/m2). CHA was defined as Ferriman-Gallwey score ≥8, BHA as presence of FAI≥6% and/or testososterone >2 nmol/l. We measured fasting glucose (FG), insulin, lipids, FSH, LH, testosterone, SHBG, androstenedione, estradiol, DHEAS and 17OHprogesterone, while HOMA-IR and FAI were calculated. Differences between-groups were age and BMI adjusted.

Results: In comparison to controls, PCOS-BHA and PCOS-CBHA had higher total cholesterol (TC) (P=0.031 and P=0.001, respectively), LH (P<0.001 and P<0.001, respectively), DHEAS (both P<0.001), all PCOS groups had higher triglycerides (P=0.006, P=0.004, P=0.001 respectively), PCOS-CBHA had higher 17Ohprogesterone (P=0.012) and PCOS-CHA had higher androstenedione (P=0.027). In comparison to PCOS-CHA, PCOS-BHA and PCOS-CBHA had higher LH (P=0.001 and P=0.026, respectively) and PCOS-CBHA had higher 17OHprogesterone (P=0.030) and TC (P=0.001). There were no between-groups differences in HOMA-IR, FSH and estradiol. Significant correlations was found among CHA between androstenedione and HOMA-IR (r=0.33, P=0.04).

Conclusions: PCOS with different forms of hyperandrogenism present with different cardiometabolic risk factors and different hormone profiles. Women with hirsutism and without hyperandrogenemia have less severe metabolic and hormonal status.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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