ECE2018 Poster Presentations: Reproductive Endocrinology Female Reproduction (48 abstracts)
Effect of maternal smoking on steroidogenesis
Monika Šrámková 1, , Michaela Dušková 1 , Karolína Adamcová 3 , Lucie Kolátorová 1 , Tereza Chlupáčová 1 , Markéta Šimková 1 , Hana Jandíková 1 , Antonín Parízek 3 & Luboslav Stárka 1
1Institute of Endocrinology, Prague, Czech Republic; 2Department of Medical Chemistry and Clinical Biochemistry, University Hospital Motol, Prague, Czech Republic; 3Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic.
Objective: Smoking during pregnancy could have impact on steroidogenesis, with more marked changes in smokers carrying boys as well as in their newborns. The aim of study was compared steroid hormones between non-smokers, ex-smokers, which stop smoking in the beginning of pregnancy, and active smokers.
Method: We focused on changes in steroidogenesis in the blood of mothers in their 37th week of pregnancy and in mixed cord blood from their newborns. Because of difference in steroid hormones due to sex of fetus, it is necessary to analyze separately results according the fetus sex. We included 47 healthy women carrying female fetuses with physiological pregnancies (22 non-smokers, 11 active smokers and 14 ex-smokers). The group of women carrying male fetus were excluded due to low numbers in the subgroups. Seventeen steroids were measured by LC-MS/MS method.
Results: We found higher androstenedione in smokers and ex-smokers compared to non-smokers at the 37th week. We found no changes in the female newborns.
Conclusion: Smoking during pregnancy, but unfortunately also stop smoking in the beginning of pregnancy, induces changes in the production of steroids in the mother. Stop smoking is required, but much earlier could bring more benefit.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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