ECE2018 Poster Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (101 abstracts)
Registry for central diabetes insipidus in Russia: prevalence and etiologies of the disease
Ekaterina Pigarova 1 , Larisa Dzeranova 1 , Zhanna Belaya 1 , Liudmila Rozhinskaya 1 , Alexander Lutsenko 1 , Galina Melnichenko 1 , Ivan Dedov 1 & The Consortium CDI 2
1Endocrinology Research Centre, Moscow, Russian Federation; 2Endocrinologists, Regions, Russian Federation.
Introduction: Epidemiological data for central diabetes insipidus (CDI) are quite sparse.
Objectives: To provide an epidemiological data on CDI in different regions of Russia (20 from 83 Federal regions).
Materials and methods: We used the Russian Registry for Central Diabetes Insipidus (RCDI) to study the epidemiological features of CDI.
Results: A total of 2004 patients with CDI were recorded, 47% women and 59% men. The most common of identified etiologies for CDI were postoperative (13,1%), head trauma (7,4%), and pathology of development of hypothalamic-pituitary region (6,9%). Less common were tumors (4,3%) and hereditary forms of CDI (4,3%). Rare forms of CDI with less than 4% overall were neuroinfection, Langergans hystiocytosis, sarcoidosis, and Sheehan syndrome. Idiopathic CDI was considered in 37% of patients, which is lower than previously reported 51%. The prevalence between participating in RCDI regions was variable from 0,65 to 10,67 cases per 100 000 population. The prevalence in Moscow city which represents a multinational population was 4,5% per 100 000 population. Nine from 20 regions have higher prevalence than that in Moscow city, with 4 of them having the prevalence twice as higher which may represent ethnic differences.
Conclusions: There is a reduction of previously reported proportion of idiopathic form of CDI which represent a progress in diagnostics. High variability in prevalence of CDI may represent ethnic differences.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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