ECE2018 Poster Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (101 abstracts)
Non-classical factors of cardiovascular risk in acromegaly
Betina Biagetti 1 , Anna Aulinas 2 , Roser Ferrer 1 , Gabriel Obiols 1 , Andrea Ciudin 1 , Belen Dalama 1 , Natividad López 1 , Esther García-Fernandez 1 , María Jose Arnau-Vives 1 & Jordi Mesa 1
1Hospital Universitari Vall d’Hebron, Barcelona, Spain;
2Hospital Universitari de Vic, Barcelona, Spain.
Background: Acromegaly (ACRO) is associated with greater cardiovascular morbidity and mortality, however, this is not entirely explained by the increase in classic cardiovascular risk factors (CVRF). C-reactive protein, galectin 3, adiponectin, B-type natriuretic peptide (BNP), apolipoprotein E, interleukin-6 and echocardiographic variables such as epicardial fat (EF) and interventricular septum thickness (IST) have been suggested as non-classical CVRF in the general population. Our hypothesis is that these non-classical CVRF could be increased in ACRO and contribute to this higher cardiovascular morbidity and mortality.
Objective: To assess if there are differences in non-classic CVRF in patients with ACRO compared with controls matched by age sex and BMI. Material and methods: We analyzed, 30 patients with ACRO (16 males, 5 with active disease) and 30 matched controls (by age, sex and body mass index (BMI)) with mean age of 53.9±11.0 years. Classic CVRFs, echocardiographic parameters and blood sample with non-classical CVRF determination. were evaluated.
Results: Both cohorts were identical regarding the presence of classical CVRF (hypertension, dyslipidemia, diabetes, and smoking). The ACRO cohort presented higher EF and IST compared to the control group (0.65±0.16 vs. 0.43±0.14 cm, P=0.001 and 11.31±1.17 vs. 10.64±1.47 mm, P=0.035, respectively). Likewise BNP was found higher in the ACRO group compared to controls (32.93±5.50 vs 11.96±2.16 pg / mL P<0.0026. No statistically significant differences were observed in other markers. In the multiple linear regression model that included (ACRO, BNP, gender, adiponectin and IST), only the presence of ACRO and BNP, were independents predictors of EF (ß: 0.34 P<0.001, and ß: 0.05 P: 0.05 and R2Adj. 0.42) influenced by adiponectin that acts as an interaction variable.
Conclusions: Patients with ACRO compared to their paired controls that were homogeneous in classic CVRF, have higher EF and BNP (influenced by adiponectin) EF and BNP have been related to increased cardiovascular complications in the general population and could explain the excess cardiovascular risk in acromegaly.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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