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Endocrine Abstracts

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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Poster Presentations: Pituitary and Neuroendocrinology

Pituitary - Basic

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Paediatric endocrinology
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Pituitary - Clinical

ea0056p776 | Pituitary - Basic | ECE2018

Pregnancy and hypopituitarism: clinical aspects and outcome

Stantonyonge Nicole , Aulinas Anna , Garcia-Patterson Apolonia , Adelantado Jose Maria , Espinos Juan Jose , Webb Susan M , Corcoy Rosa

Introduction: Pregnancy in hypopituitary women is a rare and poorly studied clinical condition. Management difficulties and obstetrical complications have been associated with this condition.Objectives: To define the characteristics, follow-up and perinatal outcomes in hypopituitary pregnant women attended at our centre.Methods: The clinical data of the hypopituitary pregnant women (deficiency of two or more pituitary hormones), an...
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ea0056p777 | Pituitary - Basic | ECE2018

Functional analysis of aryl hydrocarbon receptor (AHR) polymorphisms in pituitary adenomas (PAs) in the presence of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

Debattista Jessica , Formosa Robert , Vassallo Josanne

Background: PAs are the most frequent pituitary neoplasms, however molecular pathogenesis is largely unknown. The AHR is a ligand-activated transcription factor that regulates expression of various genes that mediate cellular response to xenobiotics. The exact functional role of two AHR single nucleotide polymorphisms (SNPs); Arginine554Lysine (Arg554Lys) and Valine570Isoleucine (Val570Ile) has not yet been established, however studies suggest that these mutations might increa...
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ea0056p778 | Pituitary - Basic | ECE2018

Comparative differential effects of secretagogues upon regulation of pituitary GH in several vertebrates

Sosa Valeria Alejandra Urban , Mendoza Jose Avila , Salas Martha Carranza , Moreno Carlos Guillermo Martinez , Munoz Maricela Luna , Aramburo Carlos

It is known that the synthesis and release of pituitary GH is controlled by complex neuroendocrine mechanisms that involve several neuropeptides, such as GHRH, SST, PACAP, TRH, GnRH, Ghrelin, among other regulators. Previous reports indicate that, during vertebrate evolution, the potency and efficacy of these secretagogues may vary and play differential effects upon GH regulation. In this work we aimed to study, in vitro, the capacity of these peptides to control the ...
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ea0056p779 | Pituitary - Basic | ECE2018

Next generation sequencing for characterization of mitochondrial genome in pituitary adenomas

Nemeth Kinga , Darvasi Otto , Liko Istvan , Szucs Nikolette , Czirjak Sandor , Reiniger Lilla , Szabo Borbala , Igaz Peter , Patocs Attila , Butz Henriett

Introduction: Disrupted mitochondrial functions and genetic variations of mitochondrial DNA (mtDNA) have been observed in different tumors. Regarding pituitary adenomas mtDNA was evaluated only in oncocytic type using PCR based methods and it showed high prevalence of Complex I variants. Next generation sequencing (NGS) allows high throughput sequencing and it is useful for accurate identification of heteroplasmy of mitochondrial genome as well.Aim: We a...
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ea0056p780 | Pituitary - Basic | ECE2018

Pituitary cell activation and recruitment in hipothyroidism

Oroz Fernando , Garcia-Lavandeira Montserrat , Perez-Romero Sihara , Garcia-Rendueles Angela , Alvarez Clara V

Pituitary stem cells have been characterized in the postnatal pituitary. We now know they are organized in a niche and co-express specific markers such as Sox2, Sox9 or Gfra2. Although many studies by our group and others have been dedicated to its characterization in situ it is under discussion their role in the maintenance and turnover of the pituitary in physiological conditions or physiological pituitary challenges. It’s not known if the stem cells are requir...
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ea0056p781 | Pituitary - Basic | ECE2018

SOM230 exerts anti-proliferative actions by reducing phospho-ERK1/2 levels in ACTH-secreting pituitary tumour cells

Treppiedi Donatella , Peverelli Erika , Giardino Elena , Catalano Rosa , Mangili Federica , Arosio Maura , Mantovani Giovanna

Currently, the multi-ligand somatostatin (SS) analogue pasireotide (SOM230) is the only pituitary-targeted drug used to treat patients with Cushing’s disease. SOM230 displays the highest affinity to somatostatin receptor type 5 (SSTR5) and compared to octreotide resulted more effective in reducing ACTH release. Despite its anti-secretory role, SOM230 has been associated with tumor shrinkage in patients subjected to long term treatment, although to date the key factors inv...
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ea0056p782 | Pituitary - Basic | ECE2018

Abstract withdrawn....
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ea0056p783 | Pituitary - Basic | ECE2018

Corticotroph pituitary adenomas: the functioning vs the silent: a gene expression study comparing differentially expressed genes in the regulation of POMC

Normann Kjersti Ringvoll , Sundaram Arvind , Oystese Kristin Astrid Berland , Lekva Tove , Eieland Alexander , Bollerslev Jens , Olarescu Nicoleta Cristina

Background: The exact mechanism behind the hypersecretion of ACTH and lack of negative cortisol feedback on POMC regulation in functional corticotroph adenomas (FCA) is unknown. Silent corticotroph adenomas (SCA) express, but do not secrete functional ACTH and have lower POMC expression. Using RT-qPCR and immunohistochemistry, previous studies have identified some POMC-transcription factors, regulators and processing enzymes to be differentially expressed between FCA and SCA. ...
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ea0056p784 | Pituitary - Basic | ECE2018

CGH array analysis of pituitary tumors revealed a highly-disrupted genome

Lasolle Helene , Elsensohn Mad-Helenie , Alix Eudeline , Bonnefille Clement , Michel Jessica , Bardel Claire , Roy Pascal , Sanlaville Damien , Raverot Gerald

Introduction: Genetic of pituitary tumors (PT) is incompletely understood. The aim of this study was to search for somatic copy number variations (CNV) in pituitary tumors and evaluate their prognostic impact on tumor recurrence.Methods: CGH array analysis (Agilent SurePrint G3 Human CGH+SNP Microarray 4×180 K) was performed on 196 fresh-frozen PT (67 gonadotroph, 31 corticotroph, 38 prolactinomas, 60 somatotroph). PT were classified according to th...
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ea0056p785 | Pituitary - Basic | ECE2018

Treatment with antidiabetic biguanide drugs directly impacts the function of multiple pituitary cell types from two non-human primate models

Leon-Gonzalez Antonio J , Vazquez-Borrego Mari C , Fuentes-Fayos Antonio C , Gahete Manuel D , Castano Justo P , Kineman Rhonda D , Luque Raul M

Antidiabetic biguanides, such as metformin (the most commonly prescribed drug to treat type 2 diabetes) and phenformin, are synthetic insulin-sensitizing agents. In addition to their well-known anti-hyperglycemic actions, biguanides are being also studied in other medical disorders due to the beneficial effects that they exert in important pathologies, including cardiovascular disease or different types of cancer. Although some scattered studies have suggested that metformin c...
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ea0056p786 | Pituitary - Basic | ECE2018

Enhanced expression of the transcriptional activators YAP and TAZ in non-secreting pituitary tumours

Xekouki Paraskevi , Lodge Emily , Li Ran , Flitsch Jorg , Bornstein Stefan , Theodoropoulou Marily , Andoniadou Cynthia

The Hippo kinase cascade is a crucial signalling pathway regulating organ growth during development in numerous organs. There is mounting evidence implicating this signalling pathway in tumour formation, where it is emerging as an anti-cancer target due to effective pharmacological inhibition of its transcriptional activators YAP/TAZ. We previously demonstrated activity of the Hippo kinase cascade in the mouse pituitary and nuclear association of YAP/TAZ with SOX2 expressing p...
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ea0056p787 | Pituitary - Basic | ECE2018

Activation of pituitary stem cells through modulation of the LATS/YAP/TAZ cascade

Lodge Emily , Russell John , Santambrogio Alice , Xekouki Paraskevi , Bornstein Stefan , Andoniadou Cynthia

Pituitary stem cells (PSCs) expressing SOX2 persist throughout life, giving rise to all pituitary endocrine lineages. These cells are highly active at early postnatal stages but this potential declines with age, rendering them mostly inactive in adulthood. The LATS/YAP/TAZ signaling cascade can influence stem cell fate and activity in multiple tissues and we previously identified activity of this axis in the developing and postnatal pituitary. Using a series of genetic manipul...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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