Endocrine Abstracts

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...

Case report: Hirsutism although common in acromegaly (24%) is not considered as the prevalent symptom of the disease. Here we describe a seventy-one year old woman with a 2-year history of hyperandronism and subtle acromegalic features (macroglossia, sleep apnea). Clinical examination showed hirsutism (Ferrimann-Gallwey score 20/34), acanthosis nigricans and mild clitoridomegaly. Blood examination revealed elevated IGF-1: 502 ng/ml (69–200 ng/ml) and standard oral glucose...