Endocrine Abstracts

The Wnt developmental pathway has been implicated in tumour growth and development in a number of tissues. Most frequently, the canonical Wnt pathway acting through the nuclear translocation of B-catenin has been the key player in driving tumour growth. However, non-canonical Wnt pathways, namely the Wnt-Calcium signalling and the Wnt-planar polarity pathways have also been found de-regulated in a number of cancers. In this study, microarray analysis on locally resected PA rev...

Introduction: The most frequently secreted hormone in pituitary adenomas is prolactin, but prolactin and growth hormone co-secretion are also seen at not an uncommon frequency. Co-secretion of growth hormone has also been reported after long-term follow up in the prolactinoma patients which well controlled with cabergoline therapy. In this case report, we aimed to discuss the results of cabergoline therapy in a case of co-secreting GH and prolactine with a normal IGF1 level an...

Case: An 18-years-old female patient suffering from headache, pituitary magnetic resonance imaging (MRI) revealed a lesion compatible with pituitary microadenoma; 8.5×5 mm in size, in the right lateral and extending to the midline of the pituitary gland. Cabergoline treatment was initiated in the external center with a prolactin level of 77 ng/ml and no other pituitary hormone abnormality. Unplanned pregnancy occurred in the patient who continued this treatment for about ...

Introduction: Various tumours have a worse prognosis in male than in female. This is also true for lactotroph tumours. Indeed it is known that aggressive and malignant tumours, resistant to dopamine agonists, are more frequent in male than female and are associated to lower ESR1 expression.Objectives: Our aims are to study the genes differentially expressed and the chromosomic alterations in lactotroph tumours between male and female and their relationsh...

Pituitary apoplexy is a rare syndrome due to a clinically overt hemorrhagic infarction, described in 2–7% of pituitary adenomas. A subclinical usually asymptomatic pituitary hemorrhage and/or infarction may be detected on routine imaging or during histopathological examination in 25–28% of patients with pituitary adenomas.Aim: We compared the clinical features and evolution of 166 patients with subclinical pituitary apoplexy (SPA) and 46 patien...

In vitro 3D cell culture systems seem to appropriately reproduce the tumor cell microenvironment, including nutrients-oxygen conditions and cell-cell interactions. These models may better mimic in vivo tumor conditions and more accurately reproduce drug treatments effects. Since most in vitro studies in neuroendocrine tumors (NETs) are performed in 2D culture systems (monolayer), we aimed to compare the monolayer system with a 3D spheroid cell cultur...

Aim: Acromegaly is associated with premature dead and a number of risk factors for cardiovascular disease (CVD). We aimed to examine the concept of cumulative GH exposure with regard to the presence these risk factors and cancer in acromegalic patients.Methods: Retrospective observational study in all acromegalic patients from 2006 to 2017 with a minimum of 3 years of follow-up. We exclude patients not treated. GH exposure was calculated as median GH or ...