Endocrine Abstracts

Introduction: PCOS is the most frequent endocrine disorder in women of reproductive age but its diagnosis remains one of the most challenging issues in endocrinology, gynecology, and reproductive medicine. Cyclic Cushing’s syndrome (CS) is a rare disorder, characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion.History: 37 years old lady presented with weight gain for 2 years duration. She has notic...

Purpose: Inferior petrosal sinus sampling (IPSS) is considered the gold standard test for the differential diagnosis of ACTH-dependent Cushing’s syndrome, but false-negative results have been reported in 1–10% cases. Cavernous sinus sampling (CSS) was suggested as a diagnostic tool in a complex ACTH-dependent Cushing’s syndrome cases.Aim: To study the role of bilateral combined cavernous and inferior petrosal sinus samplin...

Background: Prader-Willi syndrome (PWS) is a rare genetic, neurodevelopmental disorder. In adults the syndrome is characterized by muscular hypotonia, hyperphagia, increased risk of morbid obesity and behavioral problems. Endocrine insufficiencies are common, although insufficient function of the hypothalamus-pituitary-adrenal (HPA) axis seems to be rare. The effect of long term exposure to cortisol, which is associated with stress and obesity, is unknown in PWS. Measurement o...

Background: The mechanisms regulating adrenarche have not been elucidated, although evidence supports a critical role for ACTH and possibly other unidentified pituitary or adrenal contributing factors. Absent adrenarche has been described in children with a variety of sellar tumors. We describe a case series of five adults with congenital hypopituitarism and absent adrenarche.Cases: Three females and two males with “idiopathic” congenital hypop...