Endocrine Abstracts

Introduction: The availability of an increasing therapeutic arsenal for endocrine diseases seems to explain the current trend towards a decrease in the indications of endocrine surgery. However, this trend requires a detailed study before being confirmed in our setting.Objectives: We aimed to assess the trends in the performance of endocrine surgery, in children and adults, during three consecutive years (2014, 2015 and 2016) in our University Tertiary-C...

Introduction: Hyperparathyroidism-jaw tumour (HPT-JT) syndrome is a rare autosomal dominant cause of familial hyperparathyroidism associated with ossifying fibromas (OF) of the maxillofacial bones and increased risk of parathyroid carcinoma, caused by inactivating germline mutation of the cell division cycle 73 (CDC73) gene.Case report: We report the first Romanian family with HPT-JT and genetic screening of CDC73 gene. Three of the six...

Introduction: Metastatic or locally advanced prostate cancer is treated with surgical or medical hormone therapy. Preservation of the patient’s quality of life is a major parameter that influences the management at this stage. Comparative studies between both types of hormone therapy that consider the patient’s quality of life are almost nonexistent. The objective of our study is to evaluate the impact of medical and surgical castration on the quality of life in pati...

Introduction: The use of immunotherapy in oncology patients is increasing and is likely to continue to increase in the future. It is widely known that therapies have endocrinological side effects which can be serious, but maybe are also useful indicators to judge a response to the treatment. Presently, we do have not enough information regarding these side effects and their evolution.Materials and methods: Observational and retrospective study of 162 onc...

Tumour stroma formation is associated with angiogenesis and requires interactions of various different cell types, including endothelial cells and mesenchymal stem cells (MSCs), which are actively recruited into growing tumour stroma. Thyroid hormones T3 and T4 act as non-classical proangiogenic modulators mediated by non-genomic mechanisms via cell surface receptor integrin αvβ3. The deaminated T4 derivative tetrac is a specific inhibitor of thyroid hormone action a...

Introduction: LMTK3 is an oncogenic Receptor Tyrosine Kinase (RTK) implicated in resistance to endocrine therapy in breast cancer. Initially, LMTK3 was described as a regulator of Estrogen Receptor alpha (ERα) since it was found able to protect it from ubiquitin-mediated proteasomal degradation. In a cohort of breast cancer (BC) patients (n>600), LMTK3 protein levels and intronic polymorphisms were significantly associated with disease-free and overall surviv...

Gliomas constitute the most frequent type of brain tumors and are characterized by a rapid growth and high diffusion through the brain. In particular, astrocytomas are a subtype of malignant gliomas that are graded from low to high aggressiveness (i.e. grade I, II, III and IV), being grade IV (glioblastoma multiforme, GBM) the most malignant type, and one of the most common cancers in the brain and CNS. To date, surgery is the first-line therapy combined with chemotherapy or r...

Prostate cancer (PCa) is a complex and heterogeneous cancer that progresses from slow-growing, tissue-confined lesions, to highly aggressive and metastatic forms. Among the different processes involved in this progression, dysregulation of the alternative splicing mechanism, and, particularly, the generation of the spliced androgen receptor variant-7 (ARv7), plays a critical role in the pharmacological resistance of PCa patients (i.e. Abiraterone or Enzalutamide). In this cont...

Kinases represent a main therapeutic targets in cancer treatment as their impairing is related to tumor growth and progression. Despite the increasing evidence that tumor microenvironment (TME) signaling influences the behavior of surrounding cancer epithelial cells, still little is known about what changes in stromal cells influence tumor cells’ behavior. TNBC patients are still lacking an effective therapy, as not much is known about the biology of this BC tumor subtype...

Background: Primary hyperparathyroidism is one of the most common endocrine disorders caused by adenoma (80%), hyperplasia (15%) and carcinoma (5%). It is often difficult to differentiate between hyperplasia from an adenoma of a parathyroid gland. Toll/interleukin-1 receptor (TIR)-associated protein (TIRAP) is an adaptor protein for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increase...

Background: Even if a great number of studies have been developed recently, the molecular mechanisms of pathogenesis of hyperplastic lesions of the parathyroid glands are not well understood. The link between systemic inflammation and promotion of neoplasm is well established. Chronic infection and inflammation are considered two of the most prominent epigenetic and environmental factors contributing to tumor formation. Toll like receptors (TLRs) are essential components of in...