Endocrine Abstracts

Introduction and aims: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by macrophage and neutrophils in adipose tissue to released pro-inflammatory chemokines and cytokines. TREM-1 activate Janus kinase 2 (JAK2), protein kinase B (PKB/AKT) and extracellular signal related kinase (ERK1/2) pathways and upregulate the expression of genes involved in the inflammatory response. We aimed to indicate associations with serum TREM-1 levels, total sulfhydryl (SH) and malondialdhyde (MDA) levels in overweight patients.

Materials and methods: Twenty overweight patients (OG) and 20 age-matched healthy subjects (CG) (BMI 27.4±1.2 vs 21.9±2.3 kg/m², P=0.0001, respectively) were included in our study. Anthropometric measurements were performed by bioelectrical impedance (TANITA BC-420 MA). All complete blood count, biochemical and hormonal analysis associated with obesity were performed by automatic analyzer. Serum TREM-1 levels, MDA and SH levels were measured by Elisa. Homeostasis model assessment (HOMA-IR) was used as a formula: Fasting insulin (mU/l)xfasting glucose (mmol/l)/22.5

Results: Serum TREM-1(225.1±313.1 vs 45.2±17.0 pg/ml, P=0.046, respectively) and SH levels (75±148.9 and 31.7±18.7 μmol/l (P=0.033), respectively) in OG significantly higher than CG. There was no significant difference in serum MDA levels. HOMA-IR in OG was significantly higher than CG (3.2±3.4 vs1.9±1.6). A positive correlation was found between TREM-1 and fat mass (r=0.412, P=0.008).

Conclusions: We first demonstrated to high serum TREM-1 level might early inflammatory marker in overweight patients.