Does follicle stimulating hormone effect adiposity in patients with hypergonadotrophic hypogonadism: a retrospective study

Ibrahim Demirci; Cem Haymana; Nese Ersoz Gulcelik; Yusuf Alper Sonmez; Coskun Meric; Aydogan Aydogdu; Orhan Demir; Omer Azal

doi:10.1530/endoabs.56.P566

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is consistent evidence from basic and preclinical research that the disruption of estradiol signaling, accelerates fat accumulation. The excess fat seems to accumulate disproportionately in the abdominal region and leads to insulin resistance and dyslipidemia. We therefore decided to investigate the FSH – BMI and waist circumference relation in a small group of male patient with hyper gonadotrophic hypogonadism, who have similar laboratuary values of perimenopausal women.

Methods: A total of 230 young male patients with newly diagnosed hyper gonadotrophic hypogonadism (mean age: 21.16±1.79 years) were analyzed retrospectively. 77 of the patients had a diagnose of Klinefelter’s syndrome, the rest didn’t have any genetic testing. Only the measurements at the time of diagnosis (untreated) were taken. FSH, LH, total and free testosterone, estradiol were analyzed for possible correlation with BMI and waist circumference.

Results: The mean values of FSH, LH and total testosterone were all compatible with the diagnosis of hypergonadothrophic hypogonadism (Table 1). Only a slight negative correlation was found between LH and BMI. When we limited the analysis to the patients with documented diagnosis of Klinefelter’s syndrome the results were similar.

**Table 1** The demographic and metabolic parameters of the patients with hypergonadotrophic hypogonadism
	Patients (n=230)
Age (yr)	21.16 (±1.79)
Diag. of KS (n,%)	.77 (33.5%)
BMI (kg/m²⁾	22.35 (±4.03)
AC (cm)	60.06 (±35.61)
WC (cm)	71.02 (±39.51)
Total-C (mg/dl)	163.46 (±30.42)
FSH (mIU/ml)	347.64 (±33.66)
LH (mIU/ml)	27.21 (±14.85)
T.Testosterone (ng/dl)	0.93 (±0.93)
F.Testosterone (μU/ml)	8.31 (±13.56)
Estradiol (pg/mL)	22.48 (±18.67)

Conclusion: We didn’t find any significant correlation between FSH and abdominal circumference, waist circumference or BMI. The younger age and low BMI values of our study population may play role on these results. The lack of body fat distribution analysis, either by bio-impedance or radiologic imaging techniques was also a limitation of our study.

Endocrine Abstracts

P566