Endocrine Abstracts

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, conflicting results were reported. In some, although increased, the platelet counts were still in the normal range in obese patients.

Aim: In this study we aimed to observe the effect of surgical weight loss on Inflammatory hematological parameters and to observe the correlation between weight loss rate and hematological parameters.

Materials and methods: Eighty patients were included into the study and blood samples were taken at preop and at 3rd and 6th months.

Results: Decreases in NLR and MPV both 3rd and 6th months were statistically significant. PLR did not change at both 3rd and 6th months compared to baseline but PC was significantly lower at both 3rd and 6th months. Correlation analysis did not demonstrate any correlation between weight loss rate and MPV, NLR and PC but did with PLR at 3rd month however at 6th month there was no correlation between all the hematologic parameters and weight loss.

Discussion: We studied preoperatively and postoperatively MPV, NLR, PLR, PLT changes in patients who underwent bariatric surgery. Post op values demostrated improvement in MPV, decrease in NLR, PLT at 3rd and 6th months, but we observed that these changes did not correlate with weight loss rates. These data are consistent with the literature and show that the inflammation formed by obesity regresses after surgery. The fact that the changes in these parameters are independent of the weight loss rates suggests that our data primarily represent early results and secondly it may be the effect of individual metabolic differences.