ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Endocrine Disruptors (5 abstracts)
Plasma levels of perfluoroalkyl substances and risk of type II diabetes mellitus: a prospective nested case-control study
Carolina Donat-Vargas 1 , Ingvar A. Bergdahl 2 , Andreas Tornevi 2 , Maria Wennberg 2 , Johan Sommar 2 , Hannu Kiviranta 3 , Panu Rantakokko 3 , Olov Rolandsson 2 & Agneta Ækesson 1
1karolinska Institutet, Stockholm, Sweden. 2Umeå University, Umeå, Sweden. 3National Institute for Health and Welfare, Kuopio, Finland.
Background: Perfluoroalkyl Substances (PFAS) have drawn much attention due to environment bioaccumulation potential and their presence worldwide in human blood. Exposure to PFAS is suspected to induce endocrine-disrupting hormonal effects and may be involved in the development of type 2 diabetes (T2D). However, epidemiological evidence is scarce and inconsistent.
Objective: We aimed to investigate the association of PFAS plasma levels on the risk of developing T2D in a Swedish population-based cohort.
Methods: A prospective nested-case control design was applied. Middle-aged subjects participated in a medical examination, completed a lifestyle questionnaire and gave blood samples during 1990-2003. Six different PFAS were measured in plasma. During 10-year average follow-up T2D diagnosis was retrieved from medical records and later validated by specialists according to WHO criteria. A total of 158 T2D cases were matched (1:1) according to gender, age and sample date with participants without T2D (controls). Conditional logistic regressions were used to prospectively estimate the odds ratios (OR) of T2D.
Results: After adjusting for confounders, the risk of diabetes was reduced by 59% in subjects with higher levels of total PFAS in plasma (OR=0.41; 95% CI 0.18–0.96; P trend 0.045; comparing the highest to lowest tertile of the sum of the six standardized PFAS levels). Despite the similar point estimates for the specific individual PFAS (ORs from 0.48 to 0.75), statistical significance was not reached when assessed individually.
Conclusions: We observed that high levels of plasma PFAS in the general population were associated with a lower risk of developing T2D regardless other known risk factors such as age, gender, body mass index and diet. Further work is required to confirm these findings and to clarify potential mechanisms.
Volume 56
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more