Endocrine Abstracts

Introduction: It is known that fasting causes several physiological changes in the endocrine pancreas, such as insulin secretion, pancreatic islet metabolism and beta cells redox state. However, there is still no consensus about the effects of intermittent fasting (IF), a fad diet widespread by the media and adopted by individuals seeking rapid weight loss. In the present study, we sought to study the effects of the IF diet for three months in an animal model.<p class="abs...

Introduction: Altered nutritional status is a problem in itself that can complicate a patient’s disease. In our hospital, the assessment of nutritional status at hospital admission is protocolized and performed by the Clinical Laboratory automatically, through the CONUT system, for three years ago. Our hospital provides assistance to a population of 120,000 patients, from rural areas and with a high average age. Hospital admissions for cognitive impairment are increasing ...

Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by...

The skeletal muscle expresses the Glucagon-like Peptide 1 (GLP-1) receptor, although its effects in this tissue are not well known. Muscles are a major sink of energy substrates. The aim of our study was to examine the mid-term effect of Liraglutide (LIRA), a GLP-1 receptor agonist, in the expression of molecular indicators of the metabolic activity of the muscle, which includes enzymes, transporters, and intracellular signals. Twenty young Spague-Dawley male rats (350-400 g) ...

Background: Perfluoroalkyl Substances (PFAS) have drawn much attention due to environment bioaccumulation potential and their presence worldwide in human blood. Exposure to PFAS is suspected to induce endocrine-disrupting hormonal effects and may be involved in the development of type 2 diabetes (T2D). However, epidemiological evidence is scarce and inconsistent.Objective: We aimed to investigate the association of PFAS plasma levels on the risk of devel...