ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (73 abstracts)
Hyperandrogenaemia in women with type 1 diabetes mellitus; associations with lipids and lipoprotein particle size, and early vascular disease
Anjuli Gunness 1 , Agnieszka Pazderska 1 , Mohamed Ahmed 1 , Anne McGowan 1 , Niamh Phelan 1 , Gerard Boran 1 , Angela Taylor 2 , Michael O’Reilly 2 , Wiebke Arlt 2 , Kevin Moore 1 , Lucy Ann Behan 1 , Mark Sherlock 1 & James Gibney 1
1Department of Endocrinology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland; 2Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, Birmingham, UK.
Hyperandrogenaemia and polycystic ovary syndrome (PCOS) are common in women with Type 1 diabetes, but it is not known if they contribute to increased cardiovascular risk. We aimed to compare associations between androgen levels, lipid variables and early atherosclerosis in reproductive-age women with and without T1DM. 87 (16 with PCOS) women with T1DM (mean±SD; age 28.7±6.1yrs, BMI 25.4±4.4kg/m2), and 87 (16 PCOS) nondiabetic women (mean±SD; age 31.8±5.9yrs, BMI 28.3±4.01kg/m2), were studied. Androgens (LCMS), plasma lipids and lipoprotein subclasses (polyacrylamide-gel-tube-electrophoresis) and carotid-intima-media-thickness (CIMT), a validated marker of atherosclerosis were measured. In non-diabetic women SHBG correlated negatively and free testosterone positively with VLDL(r=−0.37/r=0.32), triglyceride (TG) (r=−0.26/r=0.28) and TG/HDL-C ratio(r=−0.28/r=0.29) while DHEAS correlated negatively with LDL-C(r=−0.29) (P<0.05 for all). In T1DM, SHBG correlated negatively(r=−0.26) and free testosterone positively(r=0.22) with TG and TG/HDL-C ratio(r=0.24) while androstenedione correlated positively with TC(r=0.24), VLDL (r=0.32) and LDL-C(r=0.32) (P<0.05 for all). TC, LDL-C and TG were not associated with CIMT in either group, but VLDL(r=0.59, P<0.0001) and the proportion of atherogenic small-dense LDL (sdLDL, r=0.24, P=0.04) correlated with CIMT only in women with T1DM. Androgens did not correlate with CIMT in either group. In summary, in T1DM and nondiabetic women, SHBG and free testosterone correlated with lipid and inflammatory markers characteristic of insulin resistance, but did not correlate with CIMT. VLDL and sdLDL were associated with CIMT in T1DM only. These results do not support a role of hyperandrogenaemia in atherogenesis in T1DM. The role of VLDL and sdLDL in early atherogenesis in T1DM requires further exploration.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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