ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (73 abstracts)
Association between NK cell activity and glucose regulation in type 2 diabetes patients
Jung Hye Kim , Kahui Park , Sang Bae Lee , Ji Sun Nam , Shinae Kang , Jong Suk Park , Chul Woo Ahn & Yu-Sik Kim
Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea.
Introduction: NK cells are cytotoxic lymphocytes critical to innate immunity. The purpose of this study is to find out the difference in NK cell activity between type 2 diabetes patients and controls, and to investigate the association between NK cell activity and glucose control.
Methods: Forty-nine subjects were enrolled in this study, with 23 type 2 diabetes patients and 26 normal glucose tolerant controls. Anthropometric and biochemical parameters were assessed. Homeostatic model assessment (HOMA) was calculated for insulin resistance. NK cell activity was measured using a newly developed NK Vue® Kit (ATgen, Seoul), which is a method of detecting and comparing interferon-gamma level from NK cells.
Results: NK cell activity was lower in type 2 diabetes patients compared to control subjects. There was a significant inverse linear relationship between NK cell activity and fasting plasma glucose after adjusting for age and gender (r=−0.346, P=0.045). Postprandial glucose and HbA1c showed a similar tendency with NK cell activity (r=−0.313 and −0.241, and P=0.072 and 0.17, respectively). Regression analysis showed HbA1c, fasting glucose and postprandial glucose to be independent predictors of NK cell activity (beta =−0.303, −0.360, −0.356, and P=0.034, 0.011, 0.033). There was no relationship between NK cell activity and HOMA-IR.
Conclusions: NK cell activity was lower in type 2 diabetes compared to controls, and it was significantly related to degree of hyperglycemia. A further, larger population study is warranted to confirm the possible correlation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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