Endocrine Abstracts

Objective: Diagnosis of diabetes after transplantation (NODAT) has been described in up to 25% of cases. NODAT is a metabolically complex disorder, similar to type 2 diabetes. Factors that influence the development of NODAT are: BMI, HCV and immunosuppression. Objective: to know the prevalence and incidence of diabetes mellitus (DM) in liver transplant patients of our hospital.

Patients and methods: Retrospective descriptive study of liver transplant patients. Variables analyzed: age, sex, cause of liver disease, BMI, pretransplant DM, NODAT according to ADA criteria and death. Statistical analysis: comparison of means with Student’s T and proportions using chi-square statistics, statistical program SPSS v.18 for Windows.

Results: Liver transplantation in 73 patients (85% men). Age: 54.5±7.1 years. Liver disease: alcoholic cirrhosis 44.4%; cirrhosis HCV 22.2%; cirrhosis HBV 6.3%; alcoholic cirrhosis and HCV 12.7%; alcoholic cirrhosis and HBV 4.8%; another 9.6%. BMI: women 23.7±5.2 vs men 27.4±4.3 Kg/m² (P=0.3). BMI higher in group of alcoholic cirrhosis (28.5±5.2 Kg/m², P=0.4). Prevalence of pretransplant DM was 32% (alcoholic cirrhosis 40%, cirrhosis HCV 30%, alcoholic cirrhosis and HCV 10%, P=0.9). Prevalence of NODAT was 38% (alcoholic cirrhosis 45.8%, cirrhosis HCV 29.2%, alcoholic cirrhosis and HCV 8.3%, P=0.9). No remission of pretransplant DM. Incidence of NODAT was 11.6%, lower than that described in other series (P=0.05). 33.3% hepatocarcinoma in transplanted patients, 47.6% with DM (NODAT 20%). Transplanted deceased 22.6%, 36.5% had DM (NODAT 7.9%).

Conclusions: Prevalence of pretransplant DM and NODAT is higher in alcoholic cirrhosis and HCV. BMI has a tendency to be higher in alcoholic cirrhosis. Incidence of NODAT is lower than that described in the literature.