ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (73 abstracts)
Evaluation of procalcitonin levels in diabetic and diabetic nephropathic patients
Murat Dağdeviren 1 , Esin Beyan 2 , Tanyel Sema Dağdeviren 3 , Esra Çopuroğlu 2 , Yavuz Çağır 2 , Özlem Doğan 4 , Derun Taner Ertuğrul 1 & Mustafa Altay 1
1Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Endocrinology and Metabolism, Ankara, Turkey; 2Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Internal Medicine, Ankara, Turkey; 3Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Family Practice, Ankara, Turkey; 4Ankara University, Medical Biochemistry, Ankara, Turkey.
Aim: To determine how serum procalcitonin (PCT) levels are affected in diabetic and diabetic nephropathic patients, it is important to determine whether PCT is indicative of an inflammation in these patients.
Materials and methods: The study included 175 patients (75 diabetic nephropathy (group 1), 75 diabetic (group 2) and 25 non-diabetic nephropathy (group 3)) and 75 healthy volunteers. Serum and urine creatinine, serum high sensitive C- reactive protein (HsCRP), procalcitonin, white blood cell, neutrophil, HbA1c and urinary protein values of patient and control groups were obtained. Urinary protein / creatinine ratio and eGFR were calculated.
Results: There was no significant difference between groups 1, 2, 3 and control group of the PCT values (0.20, 0.19, 0.23 and 0.19, respectively) (P> 0,05). HsCRP levels of all 3 patient groups were higher than the control group (P <0.001). There was a negative correlation between eGFR values of nephropathy patients (diabetic and non-diabetic) and PCT (P <0.001; r=−0.475) and HsCRP (P <0.001; r=−0.415) values. When diabetic nephropathy patients were compared with those below eGFR 60 and those above eGFR 60, When the eGFR values were lower than 60, the HsCRP values were higher (P<0.05); There was no difference between the PCT values (P>0.05).
Conclusion: There was no significant increase in PCT values of diabetic and diabetic nephropathy patients. However, there was a negative correlation between PCT level and eGFR.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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