Second setp in type 2 diabetes, what to choose?

Maria Rosa Alhambra Exposito; Paloma  Moreno; Ana Barrera Martin; Inmaculada Prior Sanchez; Maria Angeles Galvez Moreno

doi:10.1530/endoabs.56.P487

Introduction: In type 2 diabetes the choice of the second drug after metformina is marked by the basic characteristics of the patient.

Objetive: To analyze in real clinical practice the effectiveness of different antidiabetics.

Material and methods: Observational study including patients with type 2 diabetes, in which we added to metformina different antidiabetics. We revised them 3-6 months from change.

Results: Seventy-three patients were included, 40 were added SGLT2, 21 DDP4, 12 GLP1 agonist. There were not found different between groups in basal or 3-6 month characteristics except on BMI. 3-6 month after the change (table1), triglycerides, glucose, HbA1c and TAS were significantly lower on SGLT-2 group. On IDPP-4, only HbA1c levels were significantly lower than basal. On GLP-1, HbA1c and TAD were significantly lower.


		BASAL		FINAL	P-value
Age	SGLT2		45.17
	IDPP4		51.54
	GLP1		47.59
	p-value		0.273
Sex (♀-♂)	SGLT2		16–24
	IDPP4		14–7
	GLP1		5–7
	p-value		0.126
BMI	SGLT2	32.80		31.48	0.098
	IDPP4	26.74		25.31	0.246
	GLP1	38.11		35.10	0.216
	p-value	0.000		0.020
Total colesterol	SGLT2	187.84		170.14	0.869
	IDPP4	184.36		163.60	0.737
	GLP1	209.00		164.40	0.185
	p-value	0.625		0.950
HDL	SGLT2	37.31		42.35	0.296
	IDPP4	40.54		40.37	0.265
	GLP1	35.12		39.55	0.522
	p-value	0.690		0.866
LDL	SGLT2	115.25		102.78	0.081
	IDPP4	106.17		84.62	0.556
	GLP1	132.83		101.11	0.093
	p-value	0.386		0.531
Triglycerides	SGLT2	252.61		171.62	0.019
	IDPP4	385.00		148.12	0.237
	GLP1	290.37		170.90	0.098
	p-value	0.553		0.799
Glucose	SGLT2	240.45		136.50	0.003
	IDPP4	203.83		136.00	0.418
	GLP1	228.63		140.00	0.470
	p-value	0.591		0.768
HbA1c	SGLT2	9.65		7.16	0.000
	IDPP4	9.98		6.87	0.023
	GLP1	10.31		7.32	0.000
	p-value	0.736		0.710
TAS	SGLT2	133.46		127.86	0.001
	IDPP4	138.67		122.20	0.065
	GLP1	137.70		130.88	0.565
	p-value	0.602		0.579
TAD	SGLT2	78.94		75.05	0.302
	IDPP4	77.07		73.00	0.753
	GLP1	81.1		73.00	0.027
	p-value	0.708		0.756

Conclusion: In our series, SGLT2 improve not only glucose and HbA1c, but also systolic blood pressure and triglycerides. DPP4 improve HbA1c and GLP1 improve HbA1c and diastolic blood pressure.

Endocrine Abstracts

P487