Endocrine Abstracts

Aim: To investigate the relationship between oxidative stres markers and carotis intima media thickness in diabetic patients with microvascular complications.

Material and methods: 112 patients with type 2 diabetes mellitus and 44 healthy control subjects were included in the study. The presence of diabetic retinopathy was investigated by ocular examination. Neurological examinations were performed for neuropathy. In addition, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), nitric oxide (NO) and serum prolidase activity were measured for oxidative stress in the morning blood samples of all patients. Carotis intima media thickness (CIMT) was measured.

Results: Of the patients with type 2 diabetes mellitus, 80 (71.42%) had complications and 41 (28.58%) had no complications. When the groups were compared in terms of biochemical data; CRP levels in diabetic complication group were significantly higher than the other groups (P<0.001). Creatinine levels in diabetic complication group were significantly higher than the other groups (P<0.001). Protein levels in spot urine in diabetic complication group were significantly higher than the other groups (P<0.001). LDL levels in the diabetic complication group were significantly higher tham the others group (P=0.018). Triglyceride levels in the diabetic complication group were significantly higher than the others groups (P<0.001). There was no statistically significant difference between the groups in terms of TSH and fT4 levels. When the groups were compared in terms of oxidative stress markers; the antioxidant stress markers (CAT, SOD, GPx) were found to be lower in the diabetic complication group than the other groups (P<0.001, P<0.001, P<0.001, respectively), while oxidative stress markers (MDA and NO) were found to be higher in the diabetic complicated group. When the groups were compared in terms of CIMT; the CIMT was significantly higher in diabetic patients than in the healthy control group (P<0.001). There was statistically significant negative correlation between CIMK and antioxidant stress markers (CAT, SOD, GPx) while there was statistically significant positive correlation between CIMK and oxidant stress markers (MDA, NO).

Conclusion: In our study, serum oxidative stress parameters were found to be statistically significantly higher in diabetic patients with complications than the healthy control and diabetic patients without complications. Also we found there is positive correlation between carotis intima media thickness and oxidant stress markers.