ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes complications (72 abstracts)
Impact of systemic and local cytokine status in diabetic foot syndrome on ulcers healing rate
Maryia Mashkova 1 , Tatiana Mokhort 1 , Vitaliy Goranovb 1 , Alena Shyshko 1 , Liliya Chvatova 1 , Inessa Pukita 2 & Volha Symantovich 1
1Belarusian State Medical University, Minsk, Belarus; 2Endocrinology Medical City Center, Minsk, Belarus.
Aim: To study the relationship of cytokines level in patients with diabetic foot syndrome (SDS) with a healing rate of ulcerative defect and diabetes compensation.
Materials and methods: Twenty-four patients with DFS (DFS group) and 24 diabetic patients without foot ulcers (control group) (both groups comparable in age and other clinical and general laboratory characteristics, ongoing treatment, offloading mode). All DFS patients had chronic non-infected foot ulcers Wagner 2. Cytokine levels (IL-6,8,1,4) in the blood serum (both groups) and ulcers exudate (DFS group) were determined. Ulcer area was calculated at the first visit and in 8 weeks (if not healed).
Results: In the DFS group IL-1 and IL-6 level was significantly higher than in the control group – 94.53±3.2 vs. 34.95±1.36 and 16.33±1.02 vs. 9.27±0.27 (P<0.05) accordingly. In the DFS group IL-8 level in ulcer exudate was much higher than in the blood serum 35.56±2.5 vs. 9.76±1.84 (P<0.05). The correlation analysis revealed positive correlation between HbA1c and serum IL-1 (r=0.634, P<0.05) and IL-6 (r=0.521, P<0.05) level and IL-8 level in ulcers exudate (r=0.654, P<0.05) in the DFS group. Significant negative correlation was revealed between IL-4 level in ulcer exudate and wound healing rate in DFS group (r=−0.620, P<0.05) but no such correlation was revealed for HbA1c level.
Conclusion: Thus, the study of the local cytokine status (in ulcer exudate) in patients with DFS can help to identify new mechanisms that determine ulceration, limit and predict the course of the wound healing process.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more