Endocrine Abstracts

Background/purpose: The combination of DM and HT accelerates vascular complications and increases the risk of mortality and morbidity. Hypertension is seen in half of diabetic patients. HT can be detected in approximately 40% of newly diagnosed diabetic patients. DM frequency increased 2.5 times in hypertensive patients. The association of HT and DM is due to the common mechanism responsible for the pathogenesis of both diseases. There is a limited number of studies investigating the association of HT and DM with catecholamines and the molecule called cerebellin, which is involved in the synthesis of catecholamines, has not yet been studied. Therefore, in this study, we aimed to determine how catecholamine and cerebelline levels were affected both before and after treatment in urine and blood of patients with HT and HT+DM.

Method: This study included 30 patients with newly diagnosed hypertension, 30 patients with previously diagnosed diabetes mellitus and new hypertension, and 30 healthy volunteer were included to the study. Both before and after treatment, urine and blood samples were taken. Cerebelline, adrenaline, noradrenalin, metanephrine and normetanephrine levels were measured by ELISA. Other biochemical parameters (FBG, HbA1c, LDL, TG) were measured by autoanalyzer. In addition, the clinical characteristics of the collected patients were also recorded including age, gender, blood pressure and BMI.

Result: The BMI profile was similar among control, HT and HT+DM groups (P>0.05). There was a significant decrease in blood and urine cerebellin, metanephrine and normethanephrine levels in the study patients compared with the control group, both before and after treatment (P<0.05). When compared with the control group, the adrenaline levels in both urine and blood were increased in HT and HT+DM groups (P<0.05). When compared with the control group, a significant increase in blood noradrenalin level was observed in HT group but decreased in HT+DM group. In addition to, when compared with control group, the urine noradrenaline level was increased in both HT and HT+DM groups (P<0.05).

Conclusion: This result suggest that there is a relationship between cerebellin, catecholamine and catecholamine metabolites in HT and HT + DM patients. In the future, there is a need for further studies on the possibility that these biomarkers can give an idea about the etiopathogenesis of diseases such as HT, DM.

Key Words: Hypertension, diabetes mellitus, cerebellin, catecholamines