ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes complications (72 abstracts)
Soluble dipeptidyl peptidase-4 activity is associated with decreased renal function in patients with type 2 diabetes
Eun-Hee Cho 1 , Ji Yun Jeong 2 , Mi Young Lee 3 , Jung Min Kim 4 & Mi-Seon Shin 5
1School of Medicine, Kangwon National University, Chuncheon, Republic of Korea; 2Soonchunhyang University, Gumi, Republic of Korea; 3Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; 4Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea; 5Hanil General Hospital, Seoul, Republic of Korea.
Objective: Dipeptidyl peptidase (DPP)-4 is highly abundant in the kidney. In various chronic inflammatory diseases, soluble DPP-4 activity is used as a marker for diabetes, coronary artery disease and cancer. This study examined the association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.
Research design and methods: Soluble DPP-4 activities were measured retrospectively in a total of 120 patients with type 2 diabetes in the preserved samples from our previous coronary artery calcium score study.
Results: The mean soluble DPP-4 level was 645±152 ng/ml. Univariate analyses revealed that soluble DPP-4 activities were significantly correlated with total cholesterol (r=0.214; P=0.019), serum creatinine (r=−0.315; P<0.001), and estimated glomerular filtration rate by the modification of diet in renal disease (MDRD) (r=0.303; P=0.001). Associations between soluble DPP-4 with serum creatinine and GFR by the MDRD equation remained significant after adjustment for body mass index, age, and duration of diabetes. However, there was no association between soluble DPP-4 levels and body mass index, waist circumference, or coronary artery calcium score (CACs).
Conclusions: These data suggest that soluble serum DPP-4 activity might be used as a potential biomarker of deteriorated renal function in patients with T2D.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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