ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes complications (72 abstracts)
Association of dislipidemia and glycemic control in patients with type 1 diabetes mellitus
Elena Makhlina 1 , Tatiana Mokhort 2 , Yana Navmenova 3 , Marina Kaplieva 1 & Irina Savosteeva 3
1Gomel State Medical University, Gomel, Belarus; 2Belarusian State Medical University, Minsk, Belarus; 3SI Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus.
Objective: Assessment of the association of dyslipidemia and glycemic control in patients with type 1 diabetes mellitus
Materials and methods: 200 patients with DM 1 were examined (mean age 29.14±7.33 years, duration of DM 1 10.00±7.33 years). The study of daily glucose dynamics was carried out by the continuous glucose monitoring system (CGMS) of Medtronic MINIMED, USA. HbA1c and lipid metabolism parameters were determined by the biochemical analyzer ARCHITECT c8000, Abbott.
Results: The correlation analysis revealed a direct relationship between the level of HbA1C and the level of total cholesterol (rs=0.21; P<0.05), triglycerides (rs=0.23; P<0.05), VLDL (rs=0.23; P<0,05) and between the duration of hyperglycemia and the level of TG (rs=0.16; P<0.05), VLDL (rs=0.19; P<0.05), total cholesterol (rs=0.15; P<0.05). The duration of hypoglycemia is negatively associated with the atherogenic index (rs=−0.32; P<0.05). The minimum level of glucose directly depends on the level of TG (rs=0.14; P<0.05), VLDL (rs=0.17; P<0.05), total cholesterol (rs=0.17; P<0.05), the atherogenic index (rs=0.23; P<0.05) (Table 1).
| Indicator | Me (25;75) |
| HbA1c, % | 9,00 (7,70; 10,60) |
| The minimum level of glucose, mmol/l | 2,70 (2,20; 4,10) |
| The average level of glucose, mmol/l | 10,10 (8,30; 12,20) |
| Duration of hypoglycemia, % | 5,00 (2,00; 10,00) |
| Duration of hyperglycemia, % | 50,00 (32,00; 68,00) |
| Total cholesterol, mmol/l | 4,60 (4,00; 5,20) |
| Triglycerides, mmol/l | 0,92 (0,68; 1,37) |
| HDL (high-density lipoproteins), mmol/l | 2,08 (1,55; 2,89) |
| LDL (low-density lipoproteins), mmol/l | 1,73 (1,34; 2,42) |
| VLDL (very low density lipoproteins), mmol/l | 0,40 (0,30; 0,62) |
| Atherogenic index | 2,10 (1,60; 2,70) |
Conclusion: The association of atherogenic lipid profile with an increase in the level of HbA1c and the presence of hypoglycemic states has been proved.
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