Endocrine Abstracts

Purpose: Diabetic nephropathy is one of the leading causes of chronic kidney disease (CKD). Poor regulated glycemic control can result in progression of CKD. As diabetes mellitus (DM) and obesity can participate in development of atherosclerosis, the aim of this study was to assess the association of HbA1c and BMI in patients with CKD with intima-media thickness (IMT) as the early marker of atherosclerosis.

Methods: This cross-sectional study included 88 patients of all stages of CKD. Patients’ average age was 62.84±11.37 years. There were 56% female patients. 40% of patients had DM and 91% hypertension (HTA). HbA1c level, BMI, lipid and mineral status, kidney function and IMT were analyzed.

Results: DM cause CKD in 35.63% patients and HTA in 15%. Mean HbA1c level was 7.80±1.28 and BMI 27.19±3.59 kg/m². Average value of IMT was 1.09±0.25 mm and mean estimated glomerular filtration rate 40.59±31.15 μmol/l. HbA1c level positively correlated with serum calcium and phosphate product (CaxP) level (r=0.4, P<0.05), whereas BMI with IMT level (r=0.28, P<0.01). Binary logistic regression showed patients’ age as the independent predictor of pathological IMT value. HTA and CaxP level were the best predictors of the occurrence of carotid plaque.

Conclusions: Our study showed that HbA1c level is associated with the CaxP in patients with CKD. BMI was associated with early signs of atherosclerosis. Glycemic control and nutritional status in patients with CKD should be carefully monitored and tailored to each individual patient.