Endocrine Abstracts

Basal insulin secretion is essential for the maintenance of fasting glucose levels, especially through inhibition of excessive hepatic glucose output. Insulin glargine U300 is a novel long acting basal insulin formulation that provides more stable effect than glargine U100. Because of the pharmacokinetic properties of glargine U300, the expected plasma insulin concentration is not achieved during the first 4 days of treatment. We report a case of diabetic ketoacidosis in the f...

Introduction: Hyperthyroidism is defined as thyroid hyperfunction due to overproduction of thyroid hormones. Graves disease is the most common cause of hyperthyroidism. Hyperthyroidism may be associated with glycemic dysregulation. We are presenting a case with diabetic ketoacidosis who had Graves disease and acute appendicitis.Case presentation: A nineteen years old female patient wtih Graves disease who had hyperthyroidism despite high dose antithyroid...

Introduction: Hypoglycemia is defined as a reduction in plasma glucose concentration to a level that may induce symptoms such as sweating, shaking, palpitation, headache, blurry vision, loss of consciousness, seizure, coma. We present a case with hypoglycemia which is due to the use of exogenous insulin.Case presentation: A 72-years-old patient with Alzheimer disease who was admitted to the emergency clinic because of unconscio...

Metformin is considered to be the first choice in the treatment of type 2 diabetes mellitus. Lactic acidosis is a rare life-threatening complication of metformin with approximately 50% overall mortality. Metformin is contraindicated in patients with factors predisposing to lactic acidosis such as impaired renal function (eGFR <30 mL/min). Herein, we present a hemodialysis patient who developed lactic acidosis after inadvertent usage of metformin.Case...

Hemoglobin A1c (HbA1c) is used for the long-term management of patients with diabetes mellitus (DM). Hemoglobin variants other than HbA1c and e-N-lysine-glycated HbA0 may cause analytical interference in determinations of HbA1c. Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. Hemoglobin J (depending on its type) has different characteristics and functions. For example hemoglobin J Capetown (α2 92Gln β2...

Introduction: Performance-enhancing drug (PED) use is currently a common practice both inside and outside the sports competition scenario, and its adverse health effects remain underappreciated.Case report: We report the case of a 26-year-old man, bodybuilding practitioner, no relevant medical history, family history of autoimmune disorders. Referred to the emergency room with polydipsia, polyuria, blurred vision associated with a post-prandial capillary...

Introduction: Maturity-onset diabetes of the young (MODY) is a form of diabetes mellitus transmitted by an autosomal dominant mode of inheritance, usually diagnosed before the age of 25 years. Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, particularly closely related with insulin resistance and type 2 diabetes mellitus. MODY and NAFLD combination has rarely been described in the literature.Case: A 25-year-old women was admitted to...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and characterized with autoantibodies to insulin in a patient without prior exposure to exogenous insulin. Medications with sulfydryl group and autoimmune diseases are known to be associated with this syndrome. Nearly 90% of the cases were reported in Japanese patients. We presented a Turkish patient with insülin autoimmune syndrome possibly caused by α-lipoic acid. A 62-year-old woman was admitted to ...

Introduction: Bariatric surgery is a revolutionary method for the treatment of morbid obesity. It is effective as far as weight control is concerned, for the prevention and treatment of diabetes mellitus and the metabolic syndrome. However, bariatric surgery may be accompanied by adverse effects if postoperatively dietary instructions are not adhered to.Aim: The aim was to present a case of a patient who underwent sleeve gastrectomy for the treatment of ...

Introduction: Bulimia is an eating disorder characterized by constant preoccupation with food, irresistible cravings for food and binge eating episodes. The data regarding the incidence of bulimia in people with diabetes are contradictory. The glycemic variations subsequent to binging and vomiting leads to complications like retinopathy, kidney or liver failure, hypoglycemic comas and electrolyte imbalances.Case presentation: A 57-year-old female, diagno...

Introduction: Pain in the groin area is frequently encountered in football players, the cause being a sport hernia, muscle tears, avulsions, sacroiliac joint pathology, etc. Local corticosteroid injections (LCIs) are often used as one of the first-line treatments in the conservative management because of their ease of delivery, low cost and efficacy.Case presentation: A 32-year-old amateur futsal player (goalkeeper) diagnosed with type 1 diabetes at the ...