Endocrine Abstracts

Objective: The objective of our study is to describe the lipid parameters of pregnant women with diabetes during the three trimesters of pregnancy.

Materials and methods: This is a retrospective study that looked at 44 diabetic pregnant women. Clinical biological data were collected from medical records. The personal history of dyslipidemia, pathologies, and medications that may interfere with lipid parameters have been eliminated.

Results: Patients in the first trimester of pregnancy had a mean age of 33.5 years +/−6.3 (33.4+/−5.8 in T2 and 33.1+/−5.5 in T3). Diabetes was type 1 in almost 100% of cases (it was type 2 in 62.5% of patients in T2 and in 60% of patients in T3). The average pre-perceptible body mass index was 27.4 kg / m2+/−4.5 (29.2 kg / m²+/−5 in T2 and 28 kg / m²+/−3.3 in T3). on average 10.7 years +/−2.1 (7.2 years +/−5.4 in T2 and 6.6 years +/−4.6 in Q3) with an average HbA1C of 9.1%+/−1, 1 (7.9%+/−0.3 in T2 and 8.1%+/−0.4 in T3). The average triglyceride level was 1.1 mmol / L+/−0.3 (1.6 mmol / L+/−0.5 in T2 and 1.7 mmol / L+/−0.4 in T3). Mean cholesterolemia was 4.5 mmol / L+/−0.7 (4.9 mmol / L+/−0.7 in T2 and 5.2 mmol / L+/−0.6 in T3). Hypercholesterolemia was noted in only one patient (18.7% in T2 and 60% in T3). Hypertriglyceridemia was also noted in one patient (in 50% of patients in T2 and in 60% of patients in T3). All patients had normal HDL-CT regardless of the trimester of pregnancy. All patients, except two in T1, were outside the LDL-CT goal, which averaged 1.03g / L+/−0.2, in T1, 1.05g / L+/−0.2 in T2 and 1.1g / L+/−0.2 in T3.

Conclusion: In our population, it has been noted that hypercholesterolemia and hypertriglyceridemia are lipid abnormalities whose frequency increases with the evolution of pregnancy. A larger sample of diabetic patients is needed to better characterize changes in lipid parameters during pregnancy.