Endocrine Abstracts

Background: Many endocrine diseases can be complicated by diabetes, due to hyperglycemic hormones and insulinresistance. The aim of the work was to analyze prevalence, therapeutic and progressive aspects of secondary diabetes as well as carbohydrate intolerance (CHI) in patients with an endocrinopathy.

Materials and methods: A retrospective study was conducted in the endocrinology and diabetology department including 161 patients followed for diabetes or CHI and endocrinopathy (hyperthyroidism, acromegaly, pheochromocytoma and hypercorticism) between 2005 and 2017 among all endocrinopathies (365 cases). Variables studied in these patients were imbalance degree, degenerative complications, treatment and evolution.

Results: Mean age was 33.5(18-71) years with a female predominance. The etiologies were represented by hypercorticismin 57 patients, acromegaly in 38 patients, pheochromocytoma in 27 patients and hyperthyroidism in 39 patients. General diabetes prevalence was 44%. Concerning etiology, diabete prevalence of acromegaly was 34%, for hypercorticism (63%), for hyperthyroidism (33.3%) and for pheochromocytoma (38%).The prevalence of IHC was 18,6%. Diabetes revealed the endocrinopathy in 30 patients. The mean HbA1c was 9.3%. The degenerative assessment had objectified a diabetic retinopathy (16%), a nephropathy (12%), a neuropathy (7%) and hypertension (50%). Therapeutic management consisted of treatment with ADO (32%) and insulintherapy (52%). Among the patients treated and cured of their endocrinopathy (69%) we noted a diabetes regression in 78% of cases and diabetes persistence with therapeutic needs regression in 22% of cases.

Conclusion: The prevalence of secondary diabetes varies according to endocrinopathy. It can reveal the disease and associated with other metabolic disorders. Adequate screening and management is recommended in the presence of endocrinopathy.