ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Cardiovascular Endocrinology and Lipid Metabolism (25 abstracts)
Soluble ST2, a promising cardiovascular biomarker, is associated with parameters of glucose and bone metabolism in subjects at cardiovascular risk
Vito Francic 1 , Martin Gaksch 2 , Verena Schwetz 1 , Christian Trummer 1 , Marlene Pandis 1 , Felix Aberer 1 , Martin Grübler 1 , Nicolas D Verheyen 3 , Winfried März 4 , Thomas R Pieber 1 , Andreas Tomaschitz 3 , Stefan Pilz 1 & Barbara Obermayer-Pietsch 1
1Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria; 2Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria; 3Division of Cardiology, Medical University of Graz, Graz, Austria; 4Synlab Holding Germany GmbH, Mannheim, Germany.
Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associations of sST2 with surrogate parameters of cardiovascular and metabolic risk in vitamin D-deficient subjects with and without T2DM.
Methods: Serum sST2 levels were measured (by Human St2/IL-33 R Quantikine ELISA Kit; R&D Systems) in 174 hypertensive, vitamin D deficient [25(OH)D < 30 ng/ml] participants of the Styrian Vitamin D Hypertension Trial (NCT02136771). After assigning cardiovascular characteristics and parameters of bone and glucose metabolism to the respective quartiles according to sST2 concentrations, we used ANOVA, Jonckheere-Terpstra tests and chi-square tests to determine the presence of significant trends. In addition, a multiple regression model was constructed after adjusting each of the parameters for age and gender.
Results: We found significant trends across quartiles of sST2 concentrations for (BMI; P=0.024), plasma glucose (P < 0.001), insulin (P < 0.001), haemoglobin A1c (HbA1c; P=0.001), HOMA-IR (P < 0.001), T2DM prevalence (P=0.007), gender (P < 0.001), gamma-glutamyl transferase (GGT; P < 0.001), mean 24-h systolic blood pressure (P=0.016), total cholesterol (P=0.001), HDL (P=0.002), LDL (P=0.004) and osteocalcin (OC; P=0.001), while C-reactive protein, pulse wave velocity, mean 24-h diastolic blood pressure, NT-proBNP, eGFR, triglycerides and time since T2DM onset showed no significant association. In a multiple regression model we found HOMA-IR to be the only significant predictor of sST2 concentrations (adj. R2 =0.124, β=0.359, P<0.001) among the parameters included in the study.
Discussion: We found higher concentrations of sST2 positively associated with parameters of glucose and bone metabolism in vitamin D deficient subjects at cardiovascular risk, with HOMA-IR showing the strongest association. The findings of our study provide additional information on the emerging role of sST2 in obesity and T2DM, while uncovering a possible link to bone metabolism via osteocalcin.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more