Endocrine Abstracts

Objective: In recent years, many studies have been conducted on the beneficial effects of vitamin D. Vitamin D have many important effects on calcium metabolism, skeletal system and also on different systems. Low serum vitamin D levels are predictors of type 2 diabetes mellitus, cancer, cardiovascular diseases, immunological diseases and even mortality. The relationships between vitamin D and cardiovascular diseases can be explained by the lipid-lowering effect of vitamin D. In many studies, there is general agreement that high serum vitamin D levels are associated with a healthy serum lipid profile. The aim of this study was to investigate whether vitamin D levels are associated with lipid levels in outpatients, and to compare the patients above and below 60 years of age.

Material and methods: The medical records of patients who applied to outpatient clinic between January 2015 and August 2017 were reviewed. 236 outpatients aged 19–88 years who had serum 25-hydroxyvitamin D (25(OH)D) levels, total cholesterol, LDL-cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride levels were included in the study. Patients’ body mass index (BMI) was calculated. Overweight was defined as BMI (kg/m²) between 25.0 and 29.9 and obesity was defined as BMI ≥30.0. Total cholesterol levels ≥200 mg/dl, LDL cholesterol levels ≥140 mg/dl and triglyceride levels ≥ 150 mg/dl were classified as high. HDL-cholesterol levels <40 mg/dl were defined as low. Serum 25(OH)D level <50 nmol/l, or <20 ng/ml, is an indication of vitamin D deficiency.

Results: This study was conducted with 236 outpatients aged 19–88 years. 46.2% of the study population were over 60 years old, 83.5% were female, 18.2% were normal weight, 50.4% were overweight and 31.4% were obese. 56.8% of the outpatients had high total cholesterol levels, 38.1% of had high LDL cholesterol levels and 30.1% of had high triglyceride levels. 14% of the outpatients had low HDL cholesterol levels. The prevalance of vitamin D deficiency was 49.6% (95% CI, 41–58%).

Conclusion: Patients with increased 25(OH)D levels in epidemiological studies; there was a significant decrease in total cholesterol, LDL cholesterol and triglyceride levels and an increase in HDL cholesterol levels (1–3). But, in our study, there was no statistically significant relationship between vitamin D deficiency and lipid profile in patients over 60 years and under 60 years of age. We planned to increase the number of patients.