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Endocrine Abstracts (2018) 56 P278 | DOI: 10.1530/endoabs.56.P278

1Department of Endocrinology, Asclepeion Hospital, Voula, Athens, Greece; 21st Department of Medicine, Asclepeion Hospital, Voula, Athens, Greece; 3Department of Urology, Asclepeion Hospital, Voula, Athens, Greece; 4Department of Microbiology and Biochemistry, Asclepeion Hospital, Voula, Athens, Greece.


Introduction: Vitamin D deficiency has been found to be associated with multiple chronic diseases, including diabetes mellitus type 1 and 2, rheumatoid arthritis and other autoimmune diseases. However, the relationship between vitamin D and cancer remains controversial. Vitamin D deficiency is widely prevalent in the general population. In accordance, vitamin D deficiency was found to be prevalent in Scotland. In a study performed in Scotland vitamin D deficiency was observed, however, no relationship with specific cancers was found. Additionally, relationship between vitamin D receptor mutations and cancer of the prostate has been observed.

Aim: The aim was to estimate the relationship between vitamin D and cancer of the prostate.

Methods: In a group of 31 patients suffering from prostate cancer 25(OH)D3 levels, PTH levels and calcium levels were measured. Observations were also performed in 31 patients, male, in the same age group serving as controls.

Results: Vitamin D, 25(OH)D3 levels, were found to be 25.32±1.9 ng/ml and 20.21±2.37 ng/ml in the group of prostate cancer patients and the control group, respectively, (P<0.001).

Conclusions: The relationship between vitamin D and cancer remains controversial. A relationship has been observed between mutations of the vitamin D receptor and cancer of the prostate. However, the relationship between vitamin D deficiency and cancer is controversial. In the present study higher vitamin D levels were observed in prostate cancer patients as compared to a control group of men within the same age group. Therefore, when administering vitamin supplementation as well as vitamin D treatment for osteoporosis or osteomalacia caution should be exercised in order to keep vitamin D levels within the normal range. It should also be noted, that 25(OH)D3 exerts its effects by binding to its receptor within the core of the cell, thereby exerting powerful, important and as yet unknown effects in the human organism.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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