Endocrine Abstracts

Beta-human chorionic gonadotropin (β-hCG) is normally produced by syncytiotrophoblasts of the placenta and may also be secreted by germ cell neoplasms. An increase of serum hCG concentration in a male patient often suggests malignant neoplasms with a trophoblastic element. Common examples include classic seminoma with syncytiotrophoblast-like giant cells, combined germ cell tumour, and choriocarcinoma. Non-gestational choriocarcinomas typically arise from gonadal...

Introduction: The Carney-Stratakis syndrome (CSS) is an inherited condition caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C or D that predispose to gastric stromal tumors (GIST) and multicentric paragangliomas (PGL). SDH acts as a tumor suppressor gene, and enzyme activity reduction is known to be oncogenic. Since 2002 there has been some scarce reports. We present a new case of CSS associated with a germline unknown significance mutation in exon 4 ...

Introduction: The GEP NEN (gastroentero-pancreatic neuroendocrine neoplasms) are 70% of all neuroendocrine tumors, but are rare in general population – constituting only 2% of the gastrointestinal tract neoplasms. Carcinoid stands for 50% of GEP NEN, most often located in the appendix and/or ileum. Although the detection of NEN is rising, their prevalence is still likely underestimated. The clinical presentation is not characteristic at the early stages of the disease, it...