Clinical case reports - Pituitary/Adrenal | 0056 | ECE2018 | 20th European Congress of Endocrinology

ea0056p86 | Clinical case reports - Pituitary/Adrenal | ECE2018

Abstract withdrawn....

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ea0056p87 | Clinical case reports - Pituitary/Adrenal | ECE2018

Long-term follow-up of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency

Elfekih Hamza , Hasni Yosra , Badr Wafa , Abdelkrim Asma Ben , Amor Bilel Ben , Maaroufi Amal , Kacem Maha , Chaieb Molka , Gribaa Moez , Ach Koussay , Saad Ali

Introduction: Congenital adrenal hyperplasia (CAH) due to an enzymatic defect in 11-beta-hydroxylase (11β-OHD) is the second most common cause of CAH representing 5-8% of cases. It is characterized by androgen excess, hypertension and hypokalemia. Here we describe the case of a patient having a CYP11B1 mutation and being followed-up during 33 years.Observation: A 36-year-old Tunisian male was diagnosed with 11β-OHD at the age of three years rev...

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ea0056p88 | Clinical case reports - Pituitary/Adrenal | ECE2018

Rhabdomyolysis in a case with severe hypokalemia and Primary Hyperaldosteronism

dyrmishi Blertina , Olldashi Taulant , Cani Majlinda , Sulaj Holta , Puca Entela , Lumi Ema

Case Report: A 47 years old female was admitted to our hospital with muscle pain, weakness of the lower extremities, faligue, muscular cramps, nausea, anorexia and elevation of blood preasure. The muscular pain started 20 days ago and got worse over the last few days, she also had difficulty walking during these time. She denied fever, trauma history, vomiting, diarrhea and diuretic or statins use in the last days. The laboratory examinaition on admission showed severely low p...

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ea0056p89 | Clinical case reports - Pituitary/Adrenal | ECE2018

Pheochromocytoma in young patient-challenges in clinical practice

Boskovic Olivera , Kovacevic Zlata , Bogojevic Milan

A pheochromocytoma is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. The tumor is malignant in 10% of cases. Although pheochromocytoma has classically been associated with von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1) there are now 10 genes that have been identified as sites of mutations leading to pheochromocytoma.Method and materials A case re...

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ea0056p90 | Clinical case reports - Pituitary/Adrenal | ECE2018

Opioid-induced secondary adrenal insufficiency

Petre Oana Alexandra , Albu Alice

Introduction: Opioids are commonly used for the treatment of pain, and their effects on the HPA (hypothalamic pituitary adrenal) axis may be under-recognised. In the present, a few non-systematic studies have investigated the effects of opioids on the HPA axis, but results have been conflicting. To our knowledge, there is only another case report of secondary adrenal insufficiency due to tramadol therapy, resulted in suppression on the HPA axis. We present the case of a 79 yea...

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ea0056p91 | Clinical case reports - Pituitary/Adrenal | ECE2018

Intracerebral hemorrhage as a first sign of pheochromocytoma

Djurdjevic Sandra Pekic , Jovanovic Vladimir , Tasic Goran , Paunovic Ivan , Tatic Svetislav , Dundjerovic Dusko , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Jemuovic Zvezdana , Djurovic Marina Nikolic , Popovic Vera , Petakov Milan

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young. Few cases of these neuroendocrine tumors which presented with intracerebral hemorrhage have been reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He has a six months history of headache, palpitations and sweating. During examination he became somnolent and devel...

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ea0056p92 | Clinical case reports - Pituitary/Adrenal | ECE2018

Severe pheochromocytoma crisis, Type B, resulting in Takotsubo-like cardiomyopathy and fulminant refractory cardiogenic shock, successfully treated with extracorporeal membrane oxygenation (ECMO) but with fatal neurological sequelae for the patient.

Tyfoxylou Ernestini , Kounadi Theodora , Markou Athina , Papanastasiou Labrini , Charalampidou Liana , Kyriazi Evangelia , Voulgaris Nikolaos , Neoklis Skampas , Pyrgakis Vlassios , Piaditis George

Introduction: Catecholamine excess causes profound vasoconstriction, resulting in reduced intravascular volume. Pheochromocytoma crisis can be further complicated with acute stress (Takotsubo-like) cardiomyopathy, attributed to the toxic catecholamine effect on the myocardium, and cardiogenic shock leading to tissue ischemia.Aim: To present a rare case of pheochromocytoma crisis, complicated with fulminant cardiogenic shock, which led to life-threatening...

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ea0056p93 | Clinical case reports - Pituitary/Adrenal | ECE2018

Functionig adrenal incidentaloma false positive for 18F-FDG-PET/TAC

Lio Serafino , Scarpa Roberta , De Bastiani Pietro

An adrenal incidentaloma >4 cm of size is considered suspected of malignancy and therefore often sent to the adrenalectomy for pathological verification. In these cases, in recent studies the role of 18F-FDG-PET / TAC has been evaluated. We report a case of 67 years old man hospitalized for abdominal pain, fever and oliguria in obese patient with a history of diabetes mellitus 2, chronic renal failure, arterial hypertension and subjected to PTCA about 10 years earlier for ...

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ea0056p94 | Clinical case reports - Pituitary/Adrenal | ECE2018

Difficult Management of Autoimmune Polyglandular Syndrome Type 1

Petrescu Denisa , Silaghi Cristina Alina , Albu Adriana , Silaghi Horatiu , Lungu Ionela , Suciu-Petrescu Malina , Bucerzan Simona , Georgescu Carmen Emanuela

Autoimmune Polyglandular Syndrome Type I (APS 1) is a rare monogenic disease, in which simultaneous or sequential dysfunctions of endocrine or nonendocrine glands appear. A 19-year-old woman was admitted for inappetence, nausea, vomiting, abdominal pain, chronic constipation, generalized paresthesia and vertigo. She was known with primary hypoparathyroidism (from the age of 5), chronic autoimmune thyroiditis, mucocutaneous candidiasis, under treatment with calcitriol, calcium,...

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ea0056p95 | Clinical case reports - Pituitary/Adrenal | ECE2018

Pitfalls in differential diagnosis of adrenal masses

Popovici Ioana Alexandra Ambarus , Chelaru Alina , Teodoriu Laura , Balaceanu Raluca , Leustean Letitia , Roata Cristian Ene , Tesloianu Anda , Preda Cristina

Introduction: Primary adrenal insufficiency (PAI) is a potentially life threatening condition. About 7580% of cases of PAI are caused by autoimmune destruction, while TB accounts for 720% of cases; however, adrenal tuberculosis is still the primary cause of PAI in developing countries. Adrenal tuberculosis is difficult to diagnose because symptoms are non-specific. Moreover, if the patient had no prior contact with TB patients, no past history of pulmonary T...

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ea0056p96 | Clinical case reports - Pituitary/Adrenal | ECE2018

From gastric sleeve to diagnosis of a rare familial multiple endocrine neoplasia type 1

Tudurean-Olteanu Anca Georgiana , Danila Radu , Nechita Mirela Claudia , Dumitrascu Andreea-Nicoleta , Preda Cristina , Leustean Letitia , Hrisca Anamaria , Ungureanu Maria Christina

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder characterized by the presence of two of the three main endocrine tumors that are parathyroid, pituitary adenomas and enteropancreatic tumors.Case-report: We report a case of a 71-year-old obese patient with repeated unsuccessful attempts to weight loss who was admitted to the surgical department for the bariatric treatment of obesity (BMI=48,22 kg/m...

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ea0056p97 | Clinical case reports - Pituitary/Adrenal | ECE2018

Primary adrenal lymphoma in an HIV patient: a rare case of bilateral adrenal tumors

Mavromati Maria , Nawej Olivier , Tsopra Olga , Al-Alwan Heba , Jornayvaz Francois , Philippe Jacques

A 44-year old male patient with HIV-1 stage C2 presented with intermittent fever and weight loss (10 kg in 3 months). He was being treated with tenofovir/emtricitabine and atazanavir, and had a CD4 levels of 705/mm3 and HIV viral load of 1400 copies/ml. Upon admission, the complete blood panel showed anaemia and thrombocytopenia (haemoglobin: 75 g/l, platelets: 98 G/l), normal white blood cell count, normal hepatic tests and renal function, normal electrolytes and a...

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ea0056p98 | Clinical case reports - Pituitary/Adrenal | ECE2018

High Adrenocorticotropic Hormone before and after bilateral adrenal surgery

Valea Ana , Turturea Roxana , Botezan Oana , Carsote Mara , Botezan Bogdan Mircea , Georgescu Carmen Emanuela

Introduction: Paraneoplastic Cushing syndrome is a rare form of endogenous ACTH (adrenocorticotropic hormone) dependent hypercortisolism. In some cases no overt ACTH secretion tumor can be found, which is why steroidogenesis inhibitors, and bilateral adrenalectomy remain the main therapeutic options.Material and method: This is a case report investigated in several centers by performing biochemical, hormonal and imagery tests.Case ...

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ea0056p99 | Clinical case reports - Pituitary/Adrenal | ECE2018

Addison’s disease due to bilateral adrenal hemorrhage as the first presentation of diffuse large B-cell lymphoma

Rajic Antonela Sabati , Kogoj Tina Krokter , Kocjan Tomaz

A 49-year-old previously healthy man suddenly felt severe and constant bilateral lumbar pain. Clinical examination was otherwise normal. Abdominal CT scan showed subacute hematomas in both adrenal glands (sized 10 cm right and 8 cm left). Basic laboratory tests were completely normal. Hormonal testing excluded pheochromocytoma and other hormonally active adrenal tumors. Adrenal insufficiency was confirmed by short Synacthen test and substitution therapy with hydrocortisone was...

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ea0056p100 | Clinical case reports - Pituitary/Adrenal | ECE2018

17- α hydroxylase deficiency in an adult female patient with hypertention and hypokalemia

Georgiou Eleni , Pappa Dimitra , Thoda Pinelopi , Sakali Anastasia-Konstantina , Gountios Ioannis , Bargiota Alexandra

Introduction: 17- α hydroxylase deficiency, an autosomal recessive disorder, is a rare cause of Congenital Adrenal Hyperplasia (CAH). The disease is usally diagnosed during infancy and childhood. We present here a rare case of an adult woman with 17-α hydroxylase deficiency diagnosed for first time in adulthood.Presentation: A 49 year old woman, with no previous medical history came to the emergency department of our hospital unconscious with G...

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ea0056p101 | Clinical case reports - Pituitary/Adrenal | ECE2018

Li-Fraumeni syndrome and adrenal tumours: case report

Tome Mariana , Guarino Jessica , Iturregui Marta

Introduction: Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults. It is a hereditary disease with high penetrance autosomal dominant transmission that is due, in 70% of the cases, to germline mutations in the gene TP53. The most common cancers associated with this disorder are brain tumors, sarcomas, breast cancer and adrenocortical tumors.Methods: We de...

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ea0056p102 | Clinical case reports - Pituitary/Adrenal | ECE2018

Addison’s disease due to bilateral adrenal hemorrhage as the firstpresentation of diffuse large B-cell lymphoma

Rajic Antonela Sabati , Kogoj Tina Krokter , Kocjan Tomaz

A 49-year-old previously healthy man suddenly felt severe and constant bilateral lumbar pain. Clinical examination was otherwise normal. Abdominal CT scan showed subacute hematomas in both adrenal glands (sized 10 cm right and 8 cm left). Basic laboratory tests were completely normal. Hormonal testing excluded pheochromocytoma and other hormonally active adrenal tumors. Adrenal insufficiency was confirmed by short Synacthen test and substitution therapy with hydrocortisone was...

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ea0056p103 | Clinical case reports - Pituitary/Adrenal | ECE2018

Paraganglioma of the prostate: a case report

Kalthoum Mehdi , Hadjkacem Faten , Elleuch Mouna , Ghorbel Dorra , Charfi Nadia , Naifer Manel , Abid Mohamed

Introduction: Extra-adrenal paragangliomas are neoplasms arising from cells of neural crest origin anywhere along the distribution of the sympathoadrenal neuroendocrine system. Nearly 85% are intra-abdominal, 12% are intrathoracic, and 3% are cervical. 1 Some of the unusual sites for paragangliomas include the kidney, urethra, urinary bladder, prostate.Case report: A 27-year old man presented with sever hypertensive crisis. He had a medical history of hi...

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ea0056p104 | Clinical case reports - Pituitary/Adrenal | ECE2018

A new gene – TMEM127 – in familial pheochromocytoma/paraganglioma syndromes

Ventura Mara , Paiva Isabel , Melo Miguel , Lages Adriana , Oliveira Diana , Martins Diana , Cunha Nelson , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Introduction: Pheochromocytomas are catecholamine-producing tumors originated from the chromaffin cells of the adrenal medulla. Although usually sporadic, this tumors could be associated with germline mutations in about 40% of cases. TMEM127 has recently been identified as a novel gene conferring increased susceptibility to pheochromocytoma.Case report: A 42-year-old woman was referred to our Hospital to perform a right adrenalectomy for pheochromocytoma...

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ea0056p105 | Clinical case reports - Pituitary/Adrenal | ECE2018

Bilateral adrenal mass revealing a pheochromocytoma and an adrenocortical adenoma in a young women: a case report

Atraki Sara , ElAziz Siham , Chadli Asmaa

A 44-year-old women without personal or familial pathological history, presented 8 months before her admission a paroxystic symptomatology made of palpitations, headache and profus sweat associated with major abdominal pain, evolving in a context of alteration of the general state. Clinical examination objectified high blood pressure and tachycardia. Laboratory testing confirmed the diagnosis of pheochromocytoma. A computed tomography of the abdomen revealed a bilateral adrena...

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ea0056p106 | Clinical case reports - Pituitary/Adrenal | ECE2018

Cushing’s syndrome in a patient with systemic lupus erythematosus

Kostoglou-Athanassiou Ifigenia , Spiliotis George , Athanassiou Lambros , Myriokefalitakis Ioannis

Introduction: Systemic lupus erythematosus is a systemic autoimmune disease, which often necessitates the administration of corticosteroids for its treatment. Cushings syndrome is a disorder characterized by the endogenous hypersecretion of cortisol.Aim: The aim was to describe the case of a patient who had systemic lupus erythematosus, was on therapy with corticosteroids and developed Cushings syndrome.Case description...

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Endocrine Abstracts

20th European Congress of Endocrinology

Poster Presentations: Adrenal and Neuroendocrine Tumours