Endocrine Abstracts

It is a well-known fact that vitamin D has an impact on many tissues of human body. Recent studies showed that vitamin D deficiency has an influence on inflamation indicators in several endocrine diseases (for example PCOS, graves disease). The aim of the study was to demonstrate correlation between 25-OH vitamin D concentration and chosen inflammation indicators (C-reactive protein and insulin) in patients with non-functioning adrenal incidentalomas. Seventy-one patients hospitalized in Endocrinology City Hospital in Piekary in 2015–2017 with non-functioning adrenal incidentalomas were included to the study. Exclusion criteria were adenomas producting hormones, vitamin D supplementation, liver or kidneys failure. Biochemical parameters (C-reactive protein, 25-OH vitamin D concentration, fasting glucose, insulin, HBA1C% and HOMA-IR) were obtained during routinely performed tests in the hospital and taken from the patient’s medical record. Anthropometric parameters were measured in the morning hours, in light clothes. The results were used to calculate the anthropometric indicators (BMI, BAI, VAI, WHR, WHtR). The collected data were statisstically analyzed using the Statistica 12 (P≤0.05). In the analyzed group mean concentration of 25-OH vitamin D was 20±8.4 ng/dl, fasting glucose 111.5±29.8 mg/dl, insulin 13.2±7.9 uU/mL, HBA1C% 6.1±0.7, HOMA-IR 3.8±2.9, CRP 2.8±1.1. Insulin concentration correlated possitively (P≤0.05) with BMI (r=0.46), BAI (r=0.21), WHR (r=0.12), WHtR (r=0.42). CRP was statistically higher (P≤0.05) in patients with higher BMI (r=0.13), WHR (r=0.07), WHtR (r=0.10). There was no signifficant correlation (P>0.05) demonstrated neither between 25-OH vitamin D and CRP nor 25-OH vitamin D and insulin. The study indicates that the measurement of anthropometric parameters (BMI, BAI, WHR and WHtR) could reflect CRP and insulin concentration in the analyzed group with non-functioning adrenal incidentalomas. Vitamin D concentration in the studied group of patients does not demonstrate correlation with chosen inflammatory indicators. It is worth to enlarge studied group to confirm obtained results.