Endocrine Abstracts

Introduction: Pheochromocytomas are uncommon neuroendocrine tumors arising from chromaffin cells of the adrenal medulla. The aim of our study was to assess imaging characteristics of pheochromocytomas.Methods: The study was a retrospective analysis of 23 patients with pheochromocytomas. All participants had a computed tomography scan (CT). Several clinical and radiologic features were statistically analysed.Results: The Mean age wa...

Introduction: In most patients with familial history of pheochromocytoma/paraganglioma, leads in the majorty of cases to a postive genetic testing for mutations, and what’s more in those patients with no familial antecedents, about 10–25% carry a mutation in one related gene. In these cases other aspects like, bilaterality, multiplicity or location must be taken into account.Objective: The objective of the study was to discuss the importance of...

Introduction: Pheochromocytomas are the most common tumours of adrenal medullary origin. The aim of this study is to describe the clinical manifestations, biochemical profile, preoperative pharmacological approach and hemodinamic outcomes in a series of patients with histologically proven pheochromocytoma treated in our center over 12 years.Methods/design: Descriptive analysis including patients diagnosed with pheochromocytoma after histological examinat...

Introduction: Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report aims to describe the outcomes of laparoscopic resection for pheocromocytoma focusing particularly on intraoperative hemodynamic stability and postoperative outcomes.Methods/design: Descriptive analysis including patients who underwent laparoscopic surgery for unilateral pheochromoc...

Introduction: Pheochromocytomas (PCCs) and paragangliomas (PGL) are rare but unique tumors. Only 10% of PCCs are malignant, defined by metastases. Metastases can be seen at diagnosis of the primary tumor or develop even 20 years later. Approximately half of patients with metastatic PCC/PGL have inherited SDHB mutations.Case report: A 45-year-old man was referred to Urology for curvature of the penis and painful erections. Among his medical background hig...

Introduction: Classically, hypertension (sustained or paroxysmal) is described in > 98% of diagnosed pheochromocytomas. Nowadays the systematic workup of adrenal incidentalomas has made uncovering normotensive pheochromocytomas no longer exceptional. However, normotensive pheochromocytomas have a catecholamine secretion characteristically lower than hypertensive pheochromocytomas. It must be emphasized that the perioperative hemodynamic instability is comparable in hyperte...

Introduction: Pheochromocytoma is an endocrine tumor developed in the chromaffin cells of the adrenal medulla and excessively secreting catecholamines in varying amounts and types. It represents a rare tumor, often benign, but serious considering its mainly cardiovascular complications. The purpose of our study is to specify the revelation methods of pheochromocytomas in our population.Patients and methods: Our study has included 23 cases of pheochromocy...

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder characterized by the development of multiple benign tumors of the nerves and the skin (neurofibromas) and areas of abnormal increased and decreased coloration of the skin. Pheochromocytoma develops in 0.1–5.7% of NF1 patients and plexiform neurofibroma in 30% of NF1 patients. We present a case of a 38-year-old female, without relevant personal, with a familial phenotype suggestive for NF1, evaluated for ...

Introduction: Even though most hypertensive patients have essential hypertension, in the resistant cases the prevalence of secondary hypertension is much higher; therefore its screening should be mandatory. Resistant hypertension usually causes a progressive decline of renal function if blood pressure is not adequately controlled. Such decline is often irreversible; however a timely diagnosis leading to a resolutive treatment can alleviate or even revert the progression of the...

Introduction: Pheochromocytoma is rarely associated with neurofibromatosis type 1 (NF1). We report 4 observations of hospitalized patients in theIbn Rochd University Hospital endocrinology department in Casablanca.Observation 1: A 52-year-old male patient was admitted for NF1-associated malignant pheochromocytomawith paroxysmal hypertension, Menard triad, elevated methoxylated urinary derivatives (DMU), and 11 * 8 cm right adrenal mass with hepatic metas...

Phaeochromocytomas are rare catecholamine secreting tumours with an incidence of 1:4500–1:1700 in the United States. Doxazosin and Phenoxybenzamine are alpha-1 selective and non-selective alpha blockers respectively which are commonly used to treat this condition peri-operatively. There are no randomized controlled studies comparing the effectiveness of these two medications. However, there are retrospective studies comparing these two medications; some favouring alpha-1 ...