ECE2018 Poster Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (70 abstracts)
The response of C19- Δ5-steroids to ACTH stimulation
Hana Pospíšilová 1 , Michaela Dušková 1 , Lucie Kolátorová 1 , Mikuláš Kosák 2 , Martin Hill 1 , Hana Jandíková 1 , Kateřina Šimůnková 1 , Monika Šrámková 1 & Luboslav Stárka 1
1Institute of Endocrinology, Prague, Czech Republic. 2Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
The adrenal androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, 5-androstenediol and 11β-hydroxy-androstenedione have a wide spectrum of important physiological effects. Aim of our study was to find differences in reaction of the C19 Δ5-steroids between healthy women and patients with adrenal insufficiency in various doses of Synacthen (1 ug, 10 ug and 250 ug). Our study involved seven healthy women and six premenopausal females (BMI and age matched) with primary adrenal insufficiency. C19 Δ5-steroids and their polar conjugates were measured in plasma using gas chromatography-mass spectrometry. Both free and conjugated steroids in patients did not show significant increase, in contrast to the levels in healthy controls (in all doses of Synacthen). Except for free DHEA and 7β-hydroxylated dehydroepinadrosterone derivatives, even the basal levels significantly differed between the patients with adrenal insufficiency and healthy controls. Changes of steroids conjugates during the ACTH test were insignificant in healthy controls. DHEA and its hydroxylated metabolites could be valuable markers of the integrity of the HPA axis. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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