ECE2018 Poster Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (70 abstracts)
Conjugated steroids could be a reserve stock for rapid conversion into free ones during stress
Michaela Dušková 1 , Lucie Kolátorová 1 , Katerina Šimůnková 1 , Mikuláš Kosák 2 , Martin Hill 1 , Hana Pospíšilová 1 , Hana Jandíková 2 , Monika Šrámková 1 & Luboslav Stárka 1
1Institute of Endocrinology, Prague, Czech Republic; 2Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
Hypoglycaemia stimulation serves as a model of physiological function of adrenal action during the stress reaction. The study aimed to describe the differences of steroid response between hypoglycemia and various doses of Synacthen (as ACTH stimulation alone). The goal of the study was to investigate the physiology of adrenal response. Twenty four steroids were measured in plasma using gas chromatography - mass spectrometry after stimulation of 1 μg, 10 μg and 250 μg of Synacthen and after insulin administration in thirteen healthy subjects. Steroid conjugates significantly decreased in the first 20 minutes of stimulation by hypoglycemia, but did not change after 1 μg, 10 μg or 250 μg Synacthen administration. No differences between the secretion of adrenal androgens after stimulation by Synacthen or by hypoglycaemia were observed. The results suggest that the conjugated steroids in the circulation can serve as a reserve for rapid conversion into free steroids in the first minutes of the stress situation. The difference between hypoglycaemia and ACTH stimulation may be in concordance with the hypothesis that additional mechanism could be important in steroids reaction to the stress situation. This study was supported by the project MHCZ–DRO (Institute of Endocrinology – EU, 00023761) and grant 17-28692A.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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