Endocrine Abstracts

Context: Familial gestational hyperthyroidism caused by mutations of TSH receptor gene, hypersensitive to hCG, is rare. Only two mutations at the same amino acid (lys183Arg, Lys183Asn) in the leucine-rich region of the extracellular N-terminal domain of the TSH receptor have been reported.Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for weight loss (5 kgs), nausea and vomiting. Thyroid function test revealed t...

Introduction: In recent years, numerous studies on the relationship between the TSH of the first trimester of pregnancy and obstetric complications have been published, and in this context it has been recommended to treat with levothyroxine from certain values of TSH. The aim of this study was to determine the incidence of obstetric and neonatal complications in pregnancies with normal TSH (0.14 to 2.49 mcU/ml) as a basis for assessing complications in pregnancies with TSH bet...

Introduction: Although widely prescribed, the benefit of thyroid hormone replacement in subclinical hypothyroidism (SHypo) is unclear. We performed a systematic review and meta-analysis of randomized controlled trails (RCTs) to assess the impact of thyroid hormone therapy on clinical outcomes.Methods: We followed the PRISMA guidelines and registered the study protocol on PROSPERO (CRD42017055536). We searched PubMed, Embase, Web of Science, COCHRANE Libr...

Poland was considered as a mild-to-moderate iodine deficiency area according to results of a nation-wide survey conducted in early 1990-ties. The obligatory iodine prophylaxis program based on iodization of house-hold salt (30 mg of iodide/1 kg of salt) was therefore introduced in 1997.The aim of the study was to assess the real impact of the Polish iodine prophylaxis model on thyroid volume in schoolchildren.Material and methods: ...

Introduction: Several studies have suggested an association of thyrotropin (TSH) and free thyroxine (FT4) levels within the reference range with morbidity and mortality in the general population. Low free triiodothyronine (FT3) has also been associated with a poor prognosis in several conditions. However, the association between FT3 levels within the reference range and the risk of mortality in the general population remains uncertain.Methods: We evaluat...