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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

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Female Reproduction

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Endocrine Case Reports
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Neuroendocrinology

ea0056gp127 | Female Reproduction | ECE2018

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Glintborg Dorte , Rubin Katrine Hass , Nybo Mads , Abrahamsen Bo , Andersen Marianne Skovsager

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation, factors linked to cardiovascular disease (CVD).Methods: National Register-based study including women with PCOS and no previous diagnosis of CVD or hypertension. PCOS OUH (n=1165) included premenopausal women with PCOS and clinical and biochemical examination. PCOS Denmark (n=18 112) included women with PCOS in the Danish National Patient...
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ea0056gp128 | Female Reproduction | ECE2018

Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines

Mancini Francesca , Milardi Domenico , Carfagna Piero , Grande Giuseppe , Miranda Vincenzo , De Cicco Nardone Alessandra , Ricciardi Domenico , Pontecorvi Alfredo , Marana Riccardo , De Cicco Nardone Fiorenzo

Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive age, up to 50% of women with infertility and up to 60% of women with dysmenorrhea. The aim of this pre-clinical study was evaluate the efficacy of low-dose SKA Progesterone (GUNA) and low-dose SKA IL-10 (GUNA) in the modulation of the inflammatory response in endomet...
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ea0056gp129 | Female Reproduction | ECE2018

Impaired GLP-1 response predicts prediabetes in obese PCOS with adverse metabolic phenotype independent of BMI

Jensterle Mojca , Ferjan Simona , Janez Andrej

Objective: Impaired glucose homeostasis in PCOS is closely linked to obesity, age and disease phenotype. The potential separate role of reduced GLP-1 response in the development of prediabetes in this population is unclear.Aim: To compare the GLP-1 response after OGTT in a cohort of obese PCOS with normal glucose tolerance (NGT) and prediabetes.Design/participants/methods: Case control study recruited 26 obese Caucasian women with ...
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ea0056gp130 | Female Reproduction | ECE2018

Alterations in gonadotropin receptors and signal activation in granulosa lutein cells from women with polycystic ovary syndrome

Owens Lisa , Christopolous Georgios , Khanjani Shirin , Hardy Kate , Lavery Stuart , Franks Stephen , Hanyaloglu Aylin

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age. The underlying pathogenesis is complex and incompletely understood. There is evidence that gonadotropin and gonadotropin receptor action play a role in the pathogenesis of PCOS with genome wide association studies in PCOS also implicating altered gonadotropin action in the aetiology of PCOS. Furthermore, our recent studies have demonstrated that gonad...
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ea0056gp131 | Female Reproduction | ECE2018

Prevalence of mutations in the insulin receptor gene and lamin A/C gene in functional ovarian hyperandrogenism with insulin resistance

Pascual-Corrales Eider , Sanmillan Jose Luis , Martinez Maria Angeles , Luque-Ramirez Manuel , Escobar-Morreale Hector

Introduction: Extreme insulin resistance monogenic syndromes, including type A insulin resistance syndrome and congenital lipodystrophies, share some phenotypic characteristics with polycystic ovary syndrome (PCOS). These conditions have an increased risk for developing cardiovascular disease and diabetes mellitus. Thus, both an early diagnosis and a personalized management are required at clinical realm.Objective: To assess the prevalence of mutations i...
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ea0056gp132 | Female Reproduction | ECE2018

Women with PCOS display reduced cardiac vagal activity which is dependent on metabolic abnormalities

Ollila Meri-Maija , Kiviniemi Antti M , Stener-Victorin Elisabet , Puukka Katri , Ruokonen Aimo , Tapanainen Juha S , Franks Stephen , Morin-Papunen Laure , Piltonen Terhi

It has been reported that women with polycystic ovary syndrome (PCOS) show cardiovascular autonomic dysfunction, with reduced parasympathetic (vagal) and increased sympathetic activity, which are known to be independent risk factors for cardiovascular morbidity and mortality. However, it is not yet clear if PCOS per se leads to cardiovascular autonomic dysfunction independently of metabolic abnormalities. In a prospective, general population-based follow-up birth coho...
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ea0056gp133 | Female Reproduction | ECE2018

Favorable prognosis of pregnancies in 28 hypopituitary women: Retrospective multicentric study on 39 pregnancies

Melloul Eve , Chabre Olivier , Caron Philippe , Young Jacques , Bry Helene , Raverot Gerald , Chazot Francoise Borson , Brosse Aurelie , Brue Thierry , Castinetti Frederic , Hoffmann Pascale , Villaret Laure

Background: Pregnancy in women with hypopituitarism has been described as presenting high risks of maternal and fetal complications but this is only based on 2 small size series.Objective: To reassess the prognosis of pregnancy in women with hypopituitarism.Methods: Multicentric, observational, retrospective study including 39 pregnancies in 28 women with gonadotropic insufficiency and at least one other pituitary hormone deficienc...
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ea0056gp134 | Female Reproduction | ECE2018

Abstract withdrawn....
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ea0056gp135 | Female Reproduction | ECE2018

Liquid chromatography-tandem mass spectrometry characterization of a broad serum and salivary steroid profile in classical form of polycystic ovary syndrome

Mezzullo Marco , Fanelli Flaminia , Zanotti Laura , Pagotto Uberto , Gambineri Alessandra

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among premenopausal women affecting up to 20% of the population. Even though androgen excess is the main diagnostic criterion for PCOS, the evaluation of hyperandrogenemia relies on methods with low accuracy and mainly able to measure total androgen amounts. Liquid chromatography-tandem mass spectrometry (LC–MS/MS) allows high accuracy steroids measurement and if applied to saliva, it also allows the measurem...
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ea0056gp136 | Female Reproduction | ECE2018

Novel mechanisms and genes involved in the pathogenesis of primary ovarian insufficiency (POI) by whole-exome sequencing approach

Rossetti Raffaella , Ferrari Ilaria , Gentilini Davide , Persani Luca

The ovarian reserve naturally declines with age, however, 1–2% of women before 40 years experiences a premature exhaustion of the ovarian function and suffers from a fertility defect named Primary Ovarian Insufficiency (POI). The genetic origin of POI is well established and strongly supported by multiple reports of familial cases. To date, thanks to the candidate gene-discovery approach, few X-linked and autosomal genes have been associated to POI onset, but most of 46,X...
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ea0056gp137 | Female Reproduction | ECE2018

Hypothalamo-pituitary-adrenal axis sensitivity in women with polycystic ovary syndrome

Macut Djuro , Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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