Endocrine Abstracts

Objective: Vitamin D deficiency is common in polish population and seem to play role in pathogenesis of some diseases. We looked for correlation between polymorphisms BsmI, TaqI, ApaI and FokI of vitamin D receptor and vitamin D influence on goiter development.

Methods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for 25-(OH) D total and genetic research were taken. We made statistical analysis of correlation between volume of the thyroid gland, volume of the nodules and levels of vitamin D in groups of various polymorphisms.

Results: Ninety-six women with goiter size from 5.67 to 68.85 ml– mean 19.7 ml, median 15.6 ml, the total nodules volume varied from 0.1 to 39 ml mean 4.59 ml, median 0.94 ml and the control group of 50 women with thyroid volume in normal range from 5.1 to 19.9 mean 11.2, median 11.2 ml. The 25(OH)total levels varied in control group from 5.3 to 31.8 ng/ml, mean – 14.4, median 12.95, and in goiter group from 4.7 to 39.8 ng/ml, mean 15.00, median 13.3 ng/ml. Only 14% in control and 22% in goiter group had vitamin level over 20 ng/ml. We found no correlation between vitamin D level and volume of thyroid gland in goiter group and no correlation between vitamin D level and summary volume of the thyroid nodules. We analyzed all alleles variants of VDR polymorphisms in groups with and without goiter in correlation with vitamin D level. We did not found statistical correlation between VDR polymorphisms BsmI, TaqI, ApaI and FokI using x² test with goiter size or nodules size.

Discussion: VDR polymorphism may have role on impact of vitamin D deficiency on osteoporosis, osteomalacia development but we did not find change of action of vitamin D on goiter development in any type of studied polymorphism - BsmI, TaqI, ApaI and FokI. Common Vitamin D deficiency in polish population have no significant influence on goiter development independent from VDR BsmI, TaqI, ApaI and FokI polymorphism