Endocrine Abstracts

Granulomatous mastitis (GM) is an inflammatory lesion of the breast relatively rare with multiple etiologies suggested. Although most cases of GM show an association with breastfeeding and pregnancy, a minority of cases were related to hyperprolactinemia caused either by drugs dopamine antagonists or intracranial lesions, including pituitary adenoma. We report a case of a patient who had GM associated with microprolactinoma. Surgical treatment of the adenoma was indicated because of gastrointestinal intolerance of drug treatment with the effects of hyperprolactinemia on the mammary gland. Indeed it is reported in the literature a complete resolution within the inflammatory lesions and normalization of prolactin response to medical or surgical treatment of brain injury causing hyperprolactinemia, suggesting that it would be the direct cause of GM. Therefore, the authors suggest to detect pituitary tumors and to evaluate the levels of prolactin in the assessment of patients with MG recent history without breastfeeding or pregnancy and in the absence of another identified etiology.