Endocrine Abstracts

Background: Hyperprolactinemia is a common endocrine disorder. Yet, data on clinical profile of Nepalese patients with hyperprolactinemia is missing. The aim of this study was to assess the clinical profile of Nepalese patients with hyperprolactinemia.

Methodology: Retrospective clinic based study conducted at the endocrine centre Kathmandu Diabetes and Thyroid Center, Lalitpur, Nepal, in which data was collected from the patient record files of the subjects diagnosed with hyperprolactinemia within the last one and a half year (March 2013 to October 2014). The data was calculated as mean and percentage frequency.

Results: A total of 30 patients diagnosed with hyperprolactinemia(mean prolactin 145.36±145.53 ng/ml) were included in the study. Mean age of the patients was 27.3±7.3 years. Menstrual irregularity was the most common presenting problem (48%), followed by galactorrhea (34%). 14% had infertility and 7% had visual disturbances.10% each had hypothyroidism and PCOS. Pituitary adenoma was demonstrated in 37% patients and idiopathic hyperprolactinemia was seen in 33%. Drug induced hyperprolactinemia accounted for 10% of the total cases. Cabergoline was used in 92% and Bromocriptine was used in 8% patients for treatment of hyperprolactinemia.

Conclusion: Menstrual irregularity and galactorrhea were the most common presenting problems seen in hyperprolactinemia patients. Pituitary adenoma was the most common cause of hyperprolactinemia in Nepalese patients. Cabergoline was the drug of choice for treatment of hyperprolactinemia.